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DECLARATIONS
Acknowledgments
The authors would like to thank Y. Yanagisawa, K. Takeda, W. N. H. W. Hassan and T. Sato for technical
assistance and the Biomedical Research Core of Tohoku University Graduate School of Medicine for
technical support.

Authors’ contributions
Designed and performed the study, drafted the manuscript and prepared the figures: Kodama T
Interpreted the data, reviewed the manuscript: All authors

Availability of data and materials
Not applicable.

Financial support and sponsorship
The study was supported by JSPS KAKENHI [17K20077 (TK) and 17H00865 (TK)].

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2018.

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