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Mohamedi et al. J Cancer Metastasis Treat 2019;5:37 Journal of Cancer
DOI: 10.20517/2394-4722.2018.81 Metastasis and Treatment

Original Article Open Access

The molecular interaction of ADAMTS-1 and fibulin-1
and its potential contribution to breast cancer

biology

Yamina Mohamedi , Tania Fontanil 1,2,3 , Teresa Cobo , José A. Vega , Juan L. Cobo , Olivia García-
6,7
6,8
4,5
1,2
Suárez , Juan Cobo , Santiago Cal , Álvaro J. Obaya 2,9
4,5
1,2
6
1 Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo 33006, Asturias, Spain.
2 Instituto Universitario de Oncología, IUOPA, Universidad de Oviedo, Oviedo 33006, Asturias, Spain.
3 Departamento de Investigación, Clínica Ordoñez, Oviedo 33012, Asturias, Spain.
4 Instituto Asturiano de Odontología, Universidad de Oviedo, Oviedo 33006, Asturias, Spain.
5 Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Oviedo, Oviedo 33006, Asturias, Spain.
6 Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo 33006, Asturias, Spain.
7 Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Providencia, Santiago 7500912, Chile.
8 Servicio de Cirugía Maxilofacial, Hospital Universitario Central de Asturias (HUCA), Oviedo 33011, Asturias, Spain.
9 Departamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, Oviedo 33006, Asturias, Spain.
Correspondence to: Dr. Alvaro J. Obaya, Departamento de Biología Funcional, Area de Fisiología, Faculta de Medicina, Universidad
de Oviedo, Oviedo 33006, Asturias, Spain. E-mail: ajobaya@uniovi.es; Dr. Santiago Cal, Departamento de Bioquímica y Biología
Molecular, Facultad de Medicina, Universidad de Oviedo, Oviedo 33006, Asturias, Spain. E-mail: santical@uniovi.es

How to cite this article: Mohamedi Y, Fontanil T, Cobo T, Vega JA, Cobo JL, García-Suárez O, Cobo J, Cal S, Obaya AJ. The
molecular interaction of ADAMTS-1 and fibulin-1 and its potential contribution to breast cancer biology. J Cancer Metastasis
Treat 2019;5:37. http://dx.doi.org/10.20517/2394-4722.2018.81

Received: 28 Nov 2018 First Decision: 2 Jan 2019 Revised: 29 Mar 2019 Accepted: 4 Apr 2019 Published: 4 May 2019

Science Editor: William Schiemann Copy Editor: Cai-Hong Wang Production Editor: Huan-Liang Wu

Abstract
Aim: Fibulins and ADAMTSs are two families of extracellular matrix proteins implicated in key functional and
pathological processes. The fact that the fibulin-1 and ADAMTS-1 proteins interact raises new questions about the
roles of these extracellular matrix proteins in modulating tumor progression. Herein, we described the functional
implications of the interaction between fibulin-1 and ADAMTS-1 on the behavior of breast cancer cell lines.

Methods: Fibulin-1 and ADAMTS-1 were exogenously expressed in MCF-7 and MDA-MB-231 cell lines to assay the
effect of their interaction in cellular properties.

Results: ADAMTS-1 expression exacerbates tumor effects in terms of proliferation, invasion and mammosphere
formation. In contrast, the simultaneous expression of ADAMTS-1 and fibulin-1 impairs these effects. The analysis of
the expression of both proteins in human breast cancer tissue arrays provides new insights into the complex roles of
fibulin-1 and ADAMTS-1 in this type of tumor.
© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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