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Gottlieb et al. J Cancer Metastasis Treat 2018;4:37 I http://dx.doi.org/10.20517/2394-4722.2018.26 Page 7 of 14

Table 4. Summary of androgen receptor exonic mutations
AA Patients tumor Disease
Codon WT NT Mutant Context WT AA
change T-44 T-102 T-106 T-112 T-121 T-125 phenotype
Exon 4A Number of reads
37,704 68,001 33,819 15,660 20,289 59,399
Number of mutants
630 1888C T CC CGG Arg Trp 68 72
647 1941C T TCC Ser Ser 40 118 21 23 107
649 1947C T ACC Thr Thr 66
650 1950C T ACC Thr Thr 31 73 PCa
652 1955C T C CCC Pro Pro 67
658 1972C T ACC CAG Gln Stop 20 63 CAIS
672 2015C T CCC Pro Pro 21 60

Exon 4B Number of reads
2884 1317 3882 n/a 2862 6640
Number of mutants
672 2015C T CCC Pro Pro 4
678 2021C T C CTG Leu Leu 3 9
683 2047C T CCA Pro Ser 2
689 2065G A GGA Gly Arg 4
694 2080C T C CAG Gln Stop 4 4 4 7 CAIS
695 2084C T CCC Pro Leu
695 2085C T CCC Pro Pro 7 3
696 2086G A GAC Asp Asn 4 CAIS
697 2091C T TCC Ser Ser 4 5 6
705 2113C T C CTC Leu Ser 2
708 2124G A CTG GGA Leu Leu 4
709 2125G A CTG GGA Gly Arg 2 CAIS
715 2141A AA (ins A) GTA CAC His fs 6
Exon 5 Number of reads
4206 3765 4488 3705 4460 3763
Number of mutants
727 2180G A C CGC Arg His 5
731 2191G A GTG GTA Val Ala 6 4 7
734 2200C T GAC CAG Gln Stop 5 4 CAIS
739 2218T TT (ins T) ATT Gln fs 10 6 4
742 2225G A TGG Trp Stop 7 9 7 6 PCa
743 2229G A ATG GGG Met Ile 5 6 PAIS
744 2231G A ATG GGG Gly Arg 5 CAIS
746 2238G A ATG GTG Met Ile 4 4
749 2246C T GCC Ala Val 8 PCa
750 2250G A ATG GGC Met Ile 4 4 PCa
752 2255G A TGG Trp Stop 5 PCa

Exon 6 Number of reads
9612 2683 4198 3108 1434 2853
Number of mutants
775 2323C T TAC CGC Arg Cys 11 4 CAIS
779 2337C T TCC CGG Ser Ser 4
780 2338C CC (ins C) TCC CGG Arg Pro fs 3
786 2354T C GTC CGA Val Ala 3
787 2359C T GTC CGA Arg Stop 21 3 PCa, CAIS
796 2390G A TTT GGA Gly Arg 3 5 3
797 2391G A TGG CTC Trp Stop 3 CAIS
799 2395C T CTC CAA Gln Stop 20 6 6 5 5 CAIS
801 2403C T ACC CCC CAG Thr Thr 12
802 2405C T ACC CCC CAG Pro Leu 3