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Page 6 of 9                          Tokunaga et al. J Cancer Metastasis Treat 2018;4:40  I  http://dx.doi.org/10.20517/2394-4722.2017.80

               Table 4. Compararison of postoperative morbidy and mortality
                Author       Year Country/area  Approach   Number of patients (n)  Morbidity rate  Mortality rate
                Huang et al. [19]  2014  Taiwan  LG vs. RG  73 vs. 35      a 8% vs. 13%   1.4% vs. 1.4%
                Suda et al. [40]  2015  Japan  LG vs. RG    438 vs. 88     a 11% vs. 2%   0.2% vs. 1.1%
                Nakauchi et al. [17]  2016  Japan  LG vs. RG  437 vs. 84   a 12% vs. 2%   -
                Yang et al. [43]  2017  Korea  OG vs. LG vs. RG  241 vs. 511 vs. 173  a 25% vs. 12% vs. 5% 0.8% vs. 0.4% vs. 0%
                Song et al. [9]  2009  Korea  LDG (early) vs. RDG  20 vs. 20  5% vs. 5%   0% vs. 0%
                                           LDG (later) vs. RDG  20 vs. 20  10% vs. 5%     0% vs. 0%
                Kim et al. [30]  2010  Korea  ODG vs. LDG vs. RDG  12 vs. 11 vs. 16  17% vs. 9% vs. 13%  0% vs. 0% vs. 0%
                Caruso et al. [22]  2011  Italy  OG vs. RG  120 vs. 29     43% vs. 41%    3.3% vs. 0%
                Woo et al. [42]  2011  Korea  LG vs. RG     591 vs. 236    14% vs. 11%    0.3% vs. 0.4%
                Eom et al. [18]  2012  Korea  LDG vs. RDG   62 vs. 30      7% vs. 13%     0% vs. 0%
                Huang et al. [25]  2012  Korea  OG vs. LG vs. RG  586 vs. 64 vs. 39  15% vs. 16% vs. 15% 1.4% vs. 1.6% vs. 2.6%
                Kim et al. [29]  2012  Korea  OG vs. LG vs. RG  4542 vs. 861 vs. 436 11% vs. 9% vs. 10%  0.5% vs. 0.3% vs. 0.5%
                Park et al. [20]  2012  Korea  LDG vs. RDG  120 vs. 30     8% vs. 17%     0% vs. 0%
                Uyama et al. [41]  2012  Japan  LDG vs. RDG  25 vs. 225    11% vs. 17%    0% vs. 0%
                Yoon et al. [44]  2012  Korea  LTG vs. RTG  65 vs. 36      15% vs. 17%    0% vs. 0%
                Hyun et al. [26]  2013  Korea  LG vs. RG    83 vs. 38      39% vs. 47%    0% vs. 0%
                Junfeng et al. [27]  2014  America  LG vs. RG  394 vs. 120  4% vs. 6%     -
                Kim et al. [28]  2014  Korea  LDG vs. RDG   481 vs. 172    4% vs. 5%      0.6% vs. 0%
                Noshiro et al. [33]  2014  Japan  LDG vs. RDG  460 vs. 21  10% vs. 10%    0% vs. 0%
                Son et al. [39]  2014  Korea  LTG vs. RTG   58 vs. 51      22% vs. 16%    0% vs. 2.0%
                Han et al. [24]  2015  Korea  LPPG vs. RPPG  69 vs. 68     22% vs. 19%    0% vs. 0%
                Lee et al. [32]  2015  Korea  LDG vs. RDG   267 vs. 133    13% vs. 11%    -
                Seo et al. [37]  2015  Korea  LDG vs. RDG   40 vs. 40      30% vs. 28%    -
                Park et al. [35]  2015  Korea  LG vs. RG    622 vs. 148    8% vs. 8%      0.5% vs. 0%
                Cianchi et al. [23]  2016  Italy  LDG vs. RDG  41 vs. 30   12% vs. 13%    4.9% vs. 3.3%
                Kim et al. [31]  2016  Korea  LDG vs. RDG   288 vs. 87     9% vs. 6%      0.3% vs. 1.1%
                Okumura et al. [34]  2016  Korea  OG vs. RG  132 vs. 49    18% vs. 14%    0% vs. 0%
                Procopiuc et al. [36]  2016  Romania  OG vs. RG  29 vs. 18  28% vs. 22%   0% vs. 0%
                Shen et al. [38]  2016  China  LG vs. RG    330 vs. 93     10% vs. 10%    -
               a
               P < 0.05. LDG: laparoscopic distal gastrectomy; LG: laparoscopic gastrectomy; LTG: laparoscopic total gastrectomy; LPPG: laparoscopic
               pylorus preservingl gastrectomy; RDG: robotic distal gastrectomy; RG: robotic gastrectomy; RTG: robotic total gastrectomy; RPPG: robotic
               pylorus preservingl gastrectomy; ODG: open distal gastrectomy; OG: open gastrectomy

               Table 5. Studies which provided long-term survival outcomes
                Author          Year   Country/  Approach  Number of   Median Follow   5y-OS     5y-DFS
                                        area                patients   up period     (%)          (%)
                                                              (n)      (months)
                Son et al. [39]  2014  Korea    LTG vs. RTG  58 vs. 51    a 70   a 91.1 vs. 89.5  a 90.2 vs. 91.2
                Lee et al. [32]  2015  Korea    LDG vs. RDG  267 vs. 133  a 75   a N.S.      -
                Okumura et al. [34]  2016  Korea  OG vs. RG  132 vs. 49  a 58    a N.S.      -
                Junfeng et al. [27]  2014  America  LG vs. RG  394 vs. 120  19 vs. 15  69.9 vs. 67.8 (3y) -
                Han et al. [24]  2015  Korea    LPPG vs. RPPG  69 vs. 68  19 vs. 23  -       -
                Nakauchi et al. [17]  2016  Japan  LG vs. RG  437 vs. 84  42 vs. 41  88.8 vs. 86.9 (3y) 86.3 vs. 86.9 (3y)
                Procopiuc et al. [36]  2016  Romania  OG vs. RG  29 vs. 18  32 vs. 25  N.S.  -
               a median follow up period longer than 3 years. N.S.: statistically not significant difference; LDG: laparoscopic distal gastrectomy; LG:
               laparoscopic gastrectomy; LTG: laparoscopic total gastrectomy; LPPG: laparoscopic pylorus preservingl gastrectomy; RDG: robotic
               distal gastrectomy; RG: robotic gastrectomy; RTG: robotic total gastrectomy; RPPG: robotic pylorus preservingl gastrectomy; OG: open
               gastrectomy


               DISCUSSION
               RG has several absolute advantages, which include articulated devices, tremor suppression function, and
               a fine three-dimensional view, and surgeons can perform operations comfortably with these technologies.
               However, these advantages are from the surgeons’ perspective, and it is unclear whether these technologies
               applied to RG are also advantageous from the patients’ viewpoint. Theoretically, the more meticulous and
               precise surgeries are, the better the outcomes will be. However, for RG to be more widely accepted, advantages
               from the patients’ side should be demonstrated in clinical trials, ideally in prospective randomized trials.
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