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Tokunaga et al. J Cancer Metastasis Treat 2018;4:40  I  http://dx.doi.org/10.20517/2394-4722.2017.80                         Page 5 of 9

               Table 3. Comparison of operation time
                Author             Year  Country/area   Approach       Number of patients  Operation time
                                                                             (n)               (min)
                Song et al. [9]    2009   Korea      LDG (early) vs. RDG  20 vs. 20        a 290 vs. 203 **
                                                     LDG (later) vs. RDG  20 vs. 20        a 134 vs. 203 **
                Kim et al. [30]    2010   Korea      ODG vs. LDG vs. RDG  12 vs. 11 vs. 16  a 127 vs. 204 vs. 259 **
                Caruso et al. [22]  2011  Italy      OG vs. RG          120 vs. 29         a 222 vs. 290 **
                Woo et al. [42]    2011   Korea      LG vs. RG          591 vs. 236        a 171 vs. 220 **
                Eom et al. [18]    2012   Korea      LDG vs. RDG        62 vs. 30          a 189 vs. 229 **
                Huang et al. [25]  2012   Korea      OG vs. LG vs. RG   586 vs. 64 vs. 39  a 320 vs. 350 vs. 430 **
                Kim et al. [29]    2012   Korea      OG vs. LG vs. RG   4542 vs. 861 vs. 436  a 158 vs. 176 vs. 226 **
                Park et al. [20]   2012   Korea      LDG vs. RDG        120 vs. 30         a 140 vs. 218 *
                Yoon et al. [44]   2012   Korea      LTG vs. RTG        65 vs. 36          a 210 vs. 306 **
                Huang et al. [19]  2014   Taiwan     LG vs. RG          73 vs. 35          a 330 vs. 358 **
                Junfeng et al. [27]  2014  America   LG vs. RG          394 vs. 120        a 221 vs. 235 **
                Kim et al. [28]    2014   Korea      LDG vs. RDG        481 vs. 172        a 167 vs. 206 **
                Noshiro et al. [33]  2014  Japan     LDG vs. RDG        460 vs. 21         a 315 vs. 439 **
                Son et al. [39]    2014   Korea      LTG vs. RTG        58 vs. 51          a 210 vs. 264 **
                Han et al. [24]    2015   Korea      LPPG vs. RPPG      69 vs. 68          a 194 vs. 258 **
                Lee et al. [32]    2015   Korea      LDG vs. RDG        267 vs. 133        a 171 vs. 218 **
                Park et al. [35]   2015   Korea      LG vs. RG          622 vs. 148        a 189 vs. 255 **
                Suda et al. [40]   2015   Japan      LG vs. RG          438 vs. 88         a 361 vs. 381 *
                Cianchi et al. [23]  2016  Italy     LDG vs. RDG        41 vs. 30          a 262 vs. 323 **
                Kim et al. [31]    2016   Korea      LDG vs. RDG        288 vs. 87         a 230 vs. 248 **
                Nakauchi et al. [17]  2016  Japan    LG vs. RG          437 vs. 84         a 361 vs. 378 *
                Okumura et al. [34]  2016  Korea     OG vs. RG          132 vs. 49         a 174 vs. 227 **
                Procopiuc et al. [36]  2016  Romania  OG vs. RG         29 vs. 18          a 243 vs. 320 **
                Shen et al. [38]   2016   China      LG vs. RG          330 vs. 93         a 226 vs. 257 **
                Yang et al. [43]   2017   Korea      OG vs. LG vs. RG   241 vs. 511 vs. 173  a 193 vs. 174 vs. 202 **
                Uyama et al. [41]  2012   Japan      LDG vs. RDG        25 vs. 225         345 vs. 361 **
                Hyun et al. [26]   2013   Korea      LG vs. RG          83 vs. 38          220 vs. 234 **
                Seo et al. [37]    2015   Korea      LDG vs. RDG        40 vs. 40          224 vs. 243 **
                           a
               *median; **mean.  P < 0.05. LDG: laparoscopic distal gastrectomy; LG: laparoscopic gastrectomy; LTG: laparoscopic total gastrectomy;
               LPPG: laparoscopic pylorus preservingl gastrectomy; RDG: robotic distal gastrectomy; RG: robotic gastrectomy; RTG: robotic total
               gastrectomy; RPPG: robotic pylorus preservingl gastrectomy; ODG: open distal gastrectomy; OG: open gastrectomy

               Considering the total medical expense of RG, long-term outcomes of RG need to be better than those of LG,
               and should be confirmed by future prospective trials.


               PROSPECTIVE STUDIES
               Although quite a few retrospective studies already exist, the number of prospective studies, particularly that
               of prospective comparative studies, is extremely limited so far [12-14,16] .

               Kim et al.  reported the results of a prospective non-randomized comparative study. In their study, a
                        [14]
               total of 423 patients selected either RG or LG after they received a comprehensive explanation of each
               procedure, and were matched according to surgeon, extent of gastric resection, and sex. Similar early
               surgical outcomes including morbidity and mortality rate, except for longer operation time in the RG
               group were reported.

               The results of a single-center prospective randomized trial, in which patients were allocated to either open
               (n = 153) or robotic (n = 158) gastrectomy groups, were reported by Wang et al. . Similar complication rates
                                                                                 [16]
               between the groups, and less estimated blood loss, longer duration of surgery, and shorter postoperative
               hospital stay in the robotic group than the open group were reported.
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