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Tokunaga et al. J Cancer Metastasis Treat 2018;4:40  I  http://dx.doi.org/10.20517/2394-4722.2017.80                         Page 3 of 9

                                    Table 1. Advantages and disadvantages of RG vs. LG are summarized
                                Articulated devices                     RG favor
                                3D image                                RG favor
                                Tremor suppression                      RG favor
                                ergonomics                              RG favor
                                Intraoperative blood loss               Equivalent
                                Morbidity rate                          Equivalent
                                Mortality rate                          Equivalent
                                Medical expense                         LG favor
                                Operation time                          LG favor
                                          RG: robotic gastrectomy; LG: laparoscopic gastrectomy

               been published, the cost for RG is not yet reimbursed by government, and therefore patients or hospitals
               have to pay additional fees . In contrast, medical expense for LG is partially covered by national insurance
                                     [17]
               systems, and the cost burden on patients and hospitals is obviously less than for RG. The additional fee
               for RG differs between surgeries depending on how many disposable and re-usable instruments are used.
               Previously, some comparative studies investigated the difference in medical expense between RG and LG
               and reported that RG expenses were approximately twice as great [18-21] . In a prospective comparative study
               conducted in Korea, significantly higher total cost in the RG group (US$13,432) than the LG group (US$8090)
               was also reported . However, if medical expenses associated with RG decrease in the future, they will no
                              [14]
               longer be an absolute disadvantage of RG.


               COMPARISON OF SHORT-TERM SURGICAL OUTCOMES BETWEEN RG AND LG
               Short-term surgical outcomes between RG and LG have been compared in many retrospective and a few
               prospective studies [9,14-20,22-44] . Among short-term surgical outcomes, intraoperative blood loss, the duration of
               surgery, the number of retrieved lymph nodes, the incidence of postoperative complications, and the length
               of postoperative hospital stay are thought to reflect surgical quality, and were assessed in most studies.

               Intraoperative blood loss was generally equivalent or less during RG than LG [Table 2]. The magnified
               fine three-dimensional view attained in RG enables surgeons to recognize even very small vessels, and
               with articulated devices, they can surely stanch bleeding. However, the reported statistically significant
               differences in intraoperative bleeding between LG and RG were generally less than 100 mL except for one
               report from Korea , and it is unclear whether the difference is clinically significant of not. Statistically
                               [38]
               significant more blood loss in RG was also reported in two Japanese studies, but the differences were less
               than 20 mL [33,41] .


               The duration of surgery is significantly longer in RG than in LG in all report, and the difference was
               statistically significant in most series [Table 3]. Although the difference ranged from 14 to 124 min, it took
               RG generally approximately 60 min more operation time than LG. There are several probable explanations
               for longer operation time in RG. Firstly, it takes 15 to 30 min, known as docking time, to prepare before an
               operator begins the surgery at a console. Secondly, during RG, a surgeon uses four robotic arms, which is
               less than the average number of five ports used during conventional LG. Although an additional port for an
               assistant can be used in RG, it is under the assistant’s not the surgeon’s control, and is sometimes useless due
               to collisions with robotic arms. As a result, it becomes difficult to make a fine surgical field, particularly in
               patients with high visceral fat volume or advanced disease, and therefore might cause longer operation time.


               The number of retrieved lymph nodes was reported to be almost equal between RG and LG. The duration
               of postoperative hospital stay was also similar, although a few investigators reported that it was shorter
               following RG than LG.
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