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to viral hepatitis and how viral hepatitis superimpose to Zika   2.   Gulland A. Zika virus is a global public health emergency, declares
            virus infection is another topic for further research.  WHO. BMJ 2016;352:i657.
                                                              3.   Wiwanitkit S,  Wiwaitkit  V.  A febrile, asymptomatic and non-
            ZIKA VIRUS, CHRONIC LIVER PROBLEM AND                 thrombocytopenic Zika virus infection: don’t miss it! Asian Pac J Trop
                                                                  Med 2016;9:513.
            HEPATOMA                                          4.   Deng Y, Zeng L, Bao W, Xu P, Zhong G. Experience of integrated
                                                                  traditional  Chinese  and  Western  medicine  in  first  case  of  imported
            An important concern is on the Zika virus infection in the   Zika virus disease in China. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
            cases with underlying chronic liver problem. As already   2016;28:106-9.
            noted, the evidence on liver pathology in Zika virus   5.   Zheng CG, Xu Y, Jiang HQ, Yin YX, Zhang JH, Zhu WJ, Liang XJ,
                                                                  Chen MX, Ye JW, Tan LM, Luo D, Gong ST. Clinical analysis of two
            infection  is  extremely  limited.  For  the  affect  fetus,  the   cases of imported children Zika virus infection in China. Zhonghua Er
            recent  investigation  showed  no  liver  problem.   In  fact,   Ke Za Zhi 2016;54:375-8.
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            the relationship between Zika virus infection and cancer is   6.   Sarno M, Sacramento GA, Khouri R, do Rosário MS, Costa F, Archanjo
            very interesting. Recently, Benelli et al.  noted that “basic   G, Santos LA, Nery N Jr, Vasilakis N, Ko AI, de Almeida AR. Zika virus
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            epidemiological knowledge on the relationships occurring   infection and stillbirths: a case of hydrops fetalis, hydranencephaly and
            between mosquito vector activity and the spread of cancer   7.   fetal demise. PLoS Negl Trop Dis 2016;10:e0004517.
                                                                  Macnamara FN. Zika virus: a report on three cases of human infection
            is urgently needed, as well as detailed information about   during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg
            the  ability  of  Culicidae  to  transfer  viruses  or  tumor  cells   1954;48:139-45.
            among hosts over time.” Nevertheless, the long term follow-  8.   Dowall SD, Graham VA, Rayner E, Atkinson B, Hall G, Watson RJ,
            up of Zika virus affected patients, especially for those with   Bosworth A, Bonney LC, Kitchen S, Hewson R. A Susceptible Mouse
            underlying chronic hepatitis is suggested. The observation   Model for Zika Virus Infection. PLoS Negl Trop Dis 2016;10:e0004658.
            on the possible emerging hepatoma among these cases is   9.   Zmurko J, Marques RE, Schols D,  Verbeken E, Kaptein SJ, Neyts
                                                                  J.  The viral polymerase inhibitor 7-deaza-2’-c-methyladenosine is a
            recommended.                                          potent inhibitor of  in vitro Zika virus replication and delays disease
                                                                  progression in a robust mouse infection model. PLoS Negl Trop Dis
            CONCLUSION                                            2016;10:e0004695.
                                                              10.  Chippaux  A, Chippaux-Hyppolite Cl, Monteny-Vandervorst N,
            It is still inconclusive  on the exact effect of Zika virus   Souloumiac-Deprez D. Several yellow fever cases in an endemic area in
            infection on human liver. The further research on this area is   Ivory Coast: serological and epidemiological evidence. Med Trop (Mars)
                                                                  1981;41:53-61.
            recommended for hepatologists.                    11.  Dupont-Rouzeyrol M, O’Connor O, Calvez E, Daurès M, John M,
                                                                  Grangeon JP, Gourinat AC. Co-infection with Zika and dengue viruses
            Financial support and sponsorship                     in 2 patients, New Caledonia, 2014. Emerg Infect Dis 2015;21:381-2.
            Nil.                                              12.  Calvet GA, Filippis AM, Mendonça MC, Sequeira PC, Siqueira AM,
                                                                  Veloso VG, Nogueira RM, Brasil P. First detection of autochthonous
            Conflicts of interest                                 Zika  virus  transmission  in  a  HIV-infected  patient  in  Rio  de Janeiro,
                                                                  Brazil. J Clin Virol 2016 ;74:1-3.
            There are no conflicts of interest.               13.  Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong
                                                                  R, Grant L, Melish ME. Clinical and imaging findings in an infant with
            REFERENCES                                            Zika embryopathy. Clin Infect Dis 2016; DOI: 10.1093/cid/ciw324.
                                                              14.  Benelli G, Lo Iacono A, Canale A, Mehlhorn H. Mosquito vectors
            1.   Chen HL, Tang RB. Why Zika virus infection has become a public health   and  the  spread  of  cancer: an  overlooked  connection?  Parasitol Res
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