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Guerriero et al. Hepatoma Res 2019;5:6  I  http://dx.doi.org/10.20517/2394-5079.2018.108                                       Page 9 of 22


                miR-21    Up      Exosomes Single  Diagnosis HCC vs. HL + CHB 30 vs. 30 + 30  N/A  N/A  N/A  [78]
                miR-21    Up      Serum  Single    Diagnosis HCC vs. HL  97 vs. 30  N/A   N/A    N/A  [79]
                miR-21    Down    Serum  Single    Diagnosis CH vs. HL  48 vs. 89  80.0   95.6   0.91  [46]
                miR-21    Down    Serum  Single    Diagnosis HCC vs. CHB  101 vs. 89                 [46]
                miR-21    Up      Serum  Single    Diagnosis HCC vs. HL  101 vs. 89  84.0  73.5  0.87  [46]
                miR-21    Up      Serum  Single    Diagnosis HCC vs. HL  56 vs. 43  67.4  55.8   0.62  [52]
                miR-21, miR-  Up  Serum  Multiple +   Diagnosis HCC vs. CHB    118 vs. 100  N/A  N/A  0.94  [61]
                122, miR-192             AFP
                miR-21, miR-  Up  Serum  Multiple  Diagnosis HCC vs. CHB    118 vs. 100  N/A  N/A  0.90  [61]
                122, miR-192
                miR-21, miR-  Up  Serum  Multiple +   Diagnosis HCC vs. CHB + LC  118 vs. 100 +   N/A  N/A  0.88  [61]
                122, miR-192             AFP                          69
                miR-21, miR-  Up  Serum  Multiple  Diagnosis HCC vs. CHB + LC  118 vs. 100 +   N/A  N/A  0.81  [61]
                122, miR-192                                          69
                miR-21, miR-  Up  Serum  Multiple  Diagnosis HCC vs. HL + CHB   118 vs. 119 +   N/A  N/A  0.85  [61]
                122, miR-192                              + LC        100 + 69
                miR-21, miR-  Up  Serum  Multiple +   Diagnosis HCC vs. LC  118 vs. 69  N/A  N/A  0.88  [61]
                122, miR-192             AFP
                miR-21, miR-      Serum  Multiple +   Diagnosis HCC vs. HL + CH 52 vs. 43 + 42  87.0  81.0  0.91  [52]
                26a, miR-101             AFP
                miR-218   Down    Serum  Single + AFP  Diagnosis HCC vs. HL + BLD 156 vs. 64 +   N/A  N/A  0.91  [73]
                                                                      98
                miR-218   Down    Serum  Single    Diagnosis HCC vs. HL + BLD 156 vs. 64 +   66.7  69.1  0.73  [73]
                                                                      98
                miR-22, miR-      Serum  Multiple +   Diagnosis HCC vs. CHC  192 vs. 96  N/A  N/A  0.98  [60]
                199a-3p                  AFP
                miR-22, miR-      Serum  Multiple  Diagnosis HCC vs. CHC  192 vs. 96  N/A  N/A   0.66  [60]
                199a-3p
                miR-221   Up      Serum  Single    Diagnosis CH vs. HL  30 vs. 10  N/A    N/A    N/A  [56]
                miR-221   Down    Serum  Single    Diagnosis HCC vs. HL  30 vs. 10  N/A   N/A    N/A  [56]
                miR-221   Up      Serum  Single    Diagnosis LC vs. HL  30 vs. 10  N/A    N/A    N/A  [56]
                miR-221   Up      Serum  Single    Diagnosis HCC vs. HL   46 vs. 50  N/A  N/A    N/A  [72]
                miR-221   Up      Serum  Single    Diagnosis HCC vs. HL   45 vs. 45  93.3  77.8  0.94  [138]
                miR-221   Up      Serum  Single + AFP  Diagnosis HCC vs. HL   45 vs. 45  96.5  88.0     [138]
                miR-223   Down    Serum  Single    Diagnosis HCC vs. HL + CLD 39 vs. 14 + 17  97.2  94.1  0.99  [139]
                miR-223   Up      Serum  Single    Diagnosis HCC vs. HL  73 vs. 34  N/A   N/A    N/A  [45]
                miR-223   Up      Serum  Single    Diagnosis CH vs. HL  48 vs. 89  80.0   75.0   0.88  [46]
                miR-223   Up      Serum  Single    Diagnosis HCC vs. HL  101 vs. 89  80.0  76.5  0.86  [46]
                miR-223-3p  Down  Plasma  Single   Diagnosis CHB vs. HL  20 vs. 24  N/A   N/A    N/A  [43]
                miR-223-3p  Down  Plasma  Single   Diagnosis HCC vs. HL   20 vs. 28  N/A  N/A    N/A  [43]
                miR-223-3p  Down  Plasma  Single   Diagnosis LC vs. HL   20 vs. 22  N/A   N/A    N/A  [43]
                miR-223-3p  Down  Plasma  Single   Diagnosis HCC vs. HL  8 vs. 28  N/A    N/A    N/A  [44]
                miR-223-3p  Down  Plasma  Single   Diagnosis LC vs. HL  30 vs. 28  N/A    N/A    N/A  [44]
                miR-224   Up      Plasma  Single   Diagnosis HCC vs. HL  20 vs. 20  N/A   N/A    0.91  [140]
                miR-224   Up      Plasma  Single   Diagnosis HCC vs. HL  87 vs. 55  93.1  80.0   0.91  [140]
                miR-224   Up      Plasma  Single   Diagnosis HCC vs. HL   33 vs. 22  87.7  86.3  0.91  [140]
                miR-224   Up      Plasma  Single   Diagnosis HCC vs. HL   54 vs. 33  87.7  86.3  0.91  [140]
                miR-24-3p  Up     Serum  Single    Diagnosis HCC vs. HL + CLD   84 vs. 46 + 31  N/A  N/A  0.63  [67]
                miR-24-3p   Up    Serum  Single + AFP  Diagnosis HCC vs. HL + CLD   84 vs. 46 + 31  N/A  N/A  0.83  [67]
                miR-26a   Down    Serum  Single    Diagnosis HCC vs. HL + CH 52 vs. 43 + 42  75.0  70.0  0.76  [52]
                miR-29a, miR-     Serum  Multiple  Diagnosis HCC vs. CHB + LC  108 vs. 51 + 47  80.6  82.7  0.81  [141]
                29c, miR-133a,                            (T)
                miR-143, miR-
                145, miR-192,
                and miR-505
                miR-29a, miR-     Serum  Multiple  Diagnosis HCC vs. CHB + LC  153 vs. 68 + 71  74.5  89.9  0.82  [141]
                29c, miR-133a,                            (V)
                miR-143, miR-
                145, miR-192,
                and miR-505
                miR-29a, miR-     Serum  Multiple  Diagnosis HCC vs. HL + CHB  108 vs. 51 + 51   80.6  85.5  0.82  [141]
                29c, miR-133a,                            + LC (T)     + 47
                miR-143, miR-
                145, miR-192,
                and miR-505
                miR-29a, miR-     Serum  Multiple  Diagnosis HCC vs. HL + CHB  153 vs. 60 +   74.5  88.9  0.81  [141]
                29c, miR-133a,                            + LC (V)    68 + 71
                miR-143, miR-
                145, miR-192,
                and miR-505
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