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Guerriero et al. Hepatoma Res 2019;5:6 I http://dx.doi.org/10.20517/2394-5079.2018.108 Page 9 of 22

miR-21 Up Exosomes Single Diagnosis HCC vs. HL + CHB 30 vs. 30 + 30 N/A N/A N/A [78]
miR-21 Up Serum Single Diagnosis HCC vs. HL 97 vs. 30 N/A N/A N/A [79]
miR-21 Down Serum Single Diagnosis CH vs. HL 48 vs. 89 80.0 95.6 0.91 [46]
miR-21 Down Serum Single Diagnosis HCC vs. CHB 101 vs. 89 [46]
miR-21 Up Serum Single Diagnosis HCC vs. HL 101 vs. 89 84.0 73.5 0.87 [46]
miR-21 Up Serum Single Diagnosis HCC vs. HL 56 vs. 43 67.4 55.8 0.62 [52]
miR-21, miR- Up Serum Multiple + Diagnosis HCC vs. CHB 118 vs. 100 N/A N/A 0.94 [61]
122, miR-192 AFP
miR-21, miR- Up Serum Multiple Diagnosis HCC vs. CHB 118 vs. 100 N/A N/A 0.90 [61]
122, miR-192
miR-21, miR- Up Serum Multiple + Diagnosis HCC vs. CHB + LC 118 vs. 100 + N/A N/A 0.88 [61]
122, miR-192 AFP 69
miR-21, miR- Up Serum Multiple Diagnosis HCC vs. CHB + LC 118 vs. 100 + N/A N/A 0.81 [61]
122, miR-192 69
miR-21, miR- Up Serum Multiple Diagnosis HCC vs. HL + CHB 118 vs. 119 + N/A N/A 0.85 [61]
122, miR-192 + LC 100 + 69
miR-21, miR- Up Serum Multiple + Diagnosis HCC vs. LC 118 vs. 69 N/A N/A 0.88 [61]
122, miR-192 AFP
miR-21, miR- Serum Multiple + Diagnosis HCC vs. HL + CH 52 vs. 43 + 42 87.0 81.0 0.91 [52]
26a, miR-101 AFP
miR-218 Down Serum Single + AFP Diagnosis HCC vs. HL + BLD 156 vs. 64 + N/A N/A 0.91 [73]
98
miR-218 Down Serum Single Diagnosis HCC vs. HL + BLD 156 vs. 64 + 66.7 69.1 0.73 [73]
98
miR-22, miR- Serum Multiple + Diagnosis HCC vs. CHC 192 vs. 96 N/A N/A 0.98 [60]
199a-3p AFP
miR-22, miR- Serum Multiple Diagnosis HCC vs. CHC 192 vs. 96 N/A N/A 0.66 [60]
199a-3p
miR-221 Up Serum Single Diagnosis CH vs. HL 30 vs. 10 N/A N/A N/A [56]
miR-221 Down Serum Single Diagnosis HCC vs. HL 30 vs. 10 N/A N/A N/A [56]
miR-221 Up Serum Single Diagnosis LC vs. HL 30 vs. 10 N/A N/A N/A [56]
miR-221 Up Serum Single Diagnosis HCC vs. HL 46 vs. 50 N/A N/A N/A [72]
miR-221 Up Serum Single Diagnosis HCC vs. HL 45 vs. 45 93.3 77.8 0.94 [138]
miR-221 Up Serum Single + AFP Diagnosis HCC vs. HL 45 vs. 45 96.5 88.0 [138]
miR-223 Down Serum Single Diagnosis HCC vs. HL + CLD 39 vs. 14 + 17 97.2 94.1 0.99 [139]
miR-223 Up Serum Single Diagnosis HCC vs. HL 73 vs. 34 N/A N/A N/A [45]
miR-223 Up Serum Single Diagnosis CH vs. HL 48 vs. 89 80.0 75.0 0.88 [46]
miR-223 Up Serum Single Diagnosis HCC vs. HL 101 vs. 89 80.0 76.5 0.86 [46]
miR-223-3p Down Plasma Single Diagnosis CHB vs. HL 20 vs. 24 N/A N/A N/A [43]
miR-223-3p Down Plasma Single Diagnosis HCC vs. HL 20 vs. 28 N/A N/A N/A [43]
miR-223-3p Down Plasma Single Diagnosis LC vs. HL 20 vs. 22 N/A N/A N/A [43]
miR-223-3p Down Plasma Single Diagnosis HCC vs. HL 8 vs. 28 N/A N/A N/A [44]
miR-223-3p Down Plasma Single Diagnosis LC vs. HL 30 vs. 28 N/A N/A N/A [44]
miR-224 Up Plasma Single Diagnosis HCC vs. HL 20 vs. 20 N/A N/A 0.91 [140]
miR-224 Up Plasma Single Diagnosis HCC vs. HL 87 vs. 55 93.1 80.0 0.91 [140]
miR-224 Up Plasma Single Diagnosis HCC vs. HL 33 vs. 22 87.7 86.3 0.91 [140]
miR-224 Up Plasma Single Diagnosis HCC vs. HL 54 vs. 33 87.7 86.3 0.91 [140]
miR-24-3p Up Serum Single Diagnosis HCC vs. HL + CLD 84 vs. 46 + 31 N/A N/A 0.63 [67]
miR-24-3p Up Serum Single + AFP Diagnosis HCC vs. HL + CLD 84 vs. 46 + 31 N/A N/A 0.83 [67]
miR-26a Down Serum Single Diagnosis HCC vs. HL + CH 52 vs. 43 + 42 75.0 70.0 0.76 [52]
miR-29a, miR- Serum Multiple Diagnosis HCC vs. CHB + LC 108 vs. 51 + 47 80.6 82.7 0.81 [141]
29c, miR-133a, (T)
miR-143, miR-
145, miR-192,
and miR-505
miR-29a, miR- Serum Multiple Diagnosis HCC vs. CHB + LC 153 vs. 68 + 71 74.5 89.9 0.82 [141]
29c, miR-133a, (V)
miR-143, miR-
145, miR-192,
and miR-505
miR-29a, miR- Serum Multiple Diagnosis HCC vs. HL + CHB 108 vs. 51 + 51 80.6 85.5 0.82 [141]
29c, miR-133a, + LC (T) + 47
miR-143, miR-
145, miR-192,
and miR-505
miR-29a, miR- Serum Multiple Diagnosis HCC vs. HL + CHB 153 vs. 60 + 74.5 88.9 0.81 [141]
29c, miR-133a, + LC (V) 68 + 71
miR-143, miR-
145, miR-192,
and miR-505