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Guerriero et al. Hepatoma Res 2019;5:6 I http://dx.doi.org/10.20517/2394-5079.2018.108 Page 7 of 22

Table 2. Circulating miRNAs as diagnostic biomarkers of hepatocellular carcinoma
miRNA Expression Body Experimental Clinical Cohorts Sample size Sensitivity Specificity AUC Ref.
fluid setting setting comparison (%) (%)
miR-130b Up Serum Single Diagnosis HCC vs. HL+ CHB 57 vs. 30 + 29 87.7 81.4 0.91 [124]
miR-29a-3p Up Serum Single Diagnosis HCC vs. HL + LC 74 vs. 60 + 43 N/A N/A 0.71 [125]
(T)
Let-7f, miR-16, Down Serum Multiple Diagnosis HCC vs. HL 90 vs. 60 N/A N/A N/A [47]
miR-21
miR-101 Up Serum Single Diagnosis HCC vs. HL 25 vs. 20 N/A N/A N/A [126]
miR-101 Down Serum Single Diagnosis HCC vs. HL 67 vs. 30 76.1 70.0 0.79 [53]
miR-101 Down Serum Single Diagnosis HCC vs. LC 67 vs. 61 95.5 90.2 0.98 [53]
miR-101 Down Serum Single Diagnosis HCC vs. HL + CH 52 vs. 43 + 42 54.9 76.9 0.62 [52]
miR-101 Down Serum Single + AFP Diagnosis HCC vs. HL + CH 52 vs. 43 + 42 N/A N/A 0.85 [52]
miR-101, miR- Down Exosomes Multiple Diagnosis HCC vs. CHB 20 vs. 20 N/A N/A N/A [127]
106b, miR-122,
miR-195
miR-101-3p, Serum Multiple Diagnosis HCC vs. LC 24 vs. 14 84.6 94.1 0.96 [51]
miR-106b-3p
miR-101-3p, Up Plasma Multiple Diagnosis HCC vs. HL 22 vs. 11 100 100 1 [51]
miR-1246, miR-
106b-3p
miR-101-3p, Up Plasma Multiple Diagnosis HCC vs. HL + LC 7 vs. 14 + 21 N/A N/A N/A [51]
miR-1246, miR-
106b-3p
miR-101-3p, Up Plasma Multiple Diagnosis HCC vs. LC 9 vs. 6 100 92.9 0.99 [51]
miR-1246, miR-
106b-3p
miR-122 Up Serum Single Diagnosis CH vs. HL 30 vs. 10 N/A N/A N/A [56]
miR-122 Up Serum Single Diagnosis HCC vs. HL 30 vs. 10 N/A N/A N/A [56]
miR-122 Down Serum Single Diagnosis LC vs. HL 30 vs. 10 N/A N/A N/A [56]
miR-122 Up Single Diagnosis HCC vs. HL + CHB 3423 vs. 1887 68.0 73.3 0.77 [128]
+ 2403
miR-122 Up Serum Single Diagnosis HCC vs. CHB 71 vs. 45 77.6 57.8 0.63 [45]
miR-122 Up Serum Single Diagnosis HCC vs. HL 71 vs. 34 81.6 83.3 0.87 [45]
miR-122 Down Serum Single Diagnosis CH vs. HL 48 vs. 89 80.0 91.2 0.93 [46]
miR-122 Down Serum Single Diagnosis HCC vs. CHB 101 vs. 89 N/A N/A N/A [46]
miR-122 Up Serum Single Diagnosis HCC vs. HL 101 vs. 89 70.7 69.1 0.79 [46]
miR-122, let-7b Up Serum Multiple Diagnosis HCC vs. HBV- 30 vs. 47 84.8 50.0 0.65 [129]
related DN
miR-122, miR- Plasma Multiple Diagnosis HCC vs. HL (V) 196 vs. 66 83.2 93.9 0.94 [49]
192, miR-21,
miR-223, miR-
26a, miR-27a
and miR-801
miR-122, miR- Plasma Multiple Diagnosis HCC vs. CHB (V) 196 vs. 72 79.1 76.4 0.84 [49]
192, miR-21,
miR-223, miR-
26a, miR-27a
and miR-802
miR-122, miR- Plasma Multiple Diagnosis HCC vs. LC (V) 196 vs. 56 75.0 91.1 0.88 [49]
192, miR-21,
miR-223, miR-
26a, miR-27a
and miR-803
miR-122, miR- Serum Multiple + Diagnosis HCC vs. LC 192 vs. 96 N/A N/A 0.98 [60]
885-5p, miR- AFP
221, miR-181b
miR-122, miR- Serum Multiple Diagnosis HCC vs. LC 192 vs. 96 N/A N/A 0.84 [60]
885-5p, miR-
221, miR-181b
miR-122, miR- Serum Multiple + Diagnosis HCC vs. HL 192 vs. 96 N/A N/A 1 [60]
885-5p, miR- AFP
29b
miR-122, miR- Serum Multiple Diagnosis HCC vs. HL 192 vs. 96 N/A N/A 0.89 [60]
885-5p, miR-
29b
miR-122-5p Up Plasma Single Diagnosis CHB vs. HL 20 vs. 24 N/A N/A N/A [43]
miR-122-5p Up Plasma Single Diagnosis HCC vs. HL 20 vs. 28 N/A N/A N/A [43]