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Guerriero et al. Hepatoma Res 2019;5:6  I  http://dx.doi.org/10.20517/2394-5079.2018.108                                       Page 7 of 22


               Table 2. Circulating miRNAs as diagnostic biomarkers of hepatocellular carcinoma
                miRNA     Expression  Body   Experimental  Clinical   Cohorts   Sample size Sensitivity  Specificity  AUC  Ref.
                                    fluid   setting  setting  comparison           (%)     (%)
                 miR-130b  Up     Serum  Single    Diagnosis HCC vs. HL+ CHB 57 vs. 30 + 29  87.7  81.4  0.91  [124]
                 miR-29a-3p  Up   Serum  Single    Diagnosis HCC vs. HL + LC  74 vs. 60 + 43  N/A   N/A  0.71  [125]
                                                          (T)
                Let-7f, miR-16,  Down  Serum  Multiple  Diagnosis HCC vs. HL  90 vs. 60  N/A   N/A  N/A    [47]
                miR-21
                miR-101   Up      Serum  Single    Diagnosis HCC vs. HL  25 vs. 20  N/A    N/A   N/A   [126]
                miR-101   Down    Serum  Single    Diagnosis HCC vs. HL  67 vs. 30  76.1  70.0   0.79  [53]
                miR-101   Down    Serum  Single    Diagnosis HCC vs. LC  67 vs. 61  95.5  90.2   0.98  [53]
                miR-101   Down    Serum  Single    Diagnosis HCC vs. HL + CH 52 vs. 43 + 42  54.9  76.9  0.62  [52]
                miR-101   Down    Serum  Single + AFP  Diagnosis HCC vs. HL + CH 52 vs. 43 + 42  N/A   N/A  0.85  [52]
                miR-101, miR-  Down  Exosomes Multiple  Diagnosis HCC vs. CHB   20 vs. 20  N/A   N/A  N/A   [127]
                106b, miR-122,
                miR-195
                miR-101-3p,       Serum  Multiple  Diagnosis HCC vs. LC   24 vs. 14  84.6  94.1  0.96  [51]
                miR-106b-3p
                miR-101-3p,   Up  Plasma  Multiple  Diagnosis HCC vs. HL  22 vs. 11  100  100    1   [51]
                miR-1246, miR-
                106b-3p
                miR-101-3p,   Up  Plasma  Multiple  Diagnosis HCC vs. HL + LC  7 vs. 14 + 21  N/A   N/A  N/A   [51]
                miR-1246, miR-
                106b-3p
                miR-101-3p,   Up  Plasma  Multiple  Diagnosis HCC vs. LC  9 vs. 6   100   92.9   0.99  [51]
                miR-1246, miR-
                106b-3p
                miR-122   Up      Serum  Single    Diagnosis CH vs. HL  30 vs. 10  N/A     N/A   N/A    [56]
                miR-122   Up      Serum  Single    Diagnosis HCC vs. HL  30 vs. 10  N/A    N/A   N/A    [56]
                miR-122   Down    Serum  Single    Diagnosis LC vs. HL  30 vs. 10  N/A     N/A   N/A    [56]
                miR-122   Up             Single    Diagnosis HCC vs. HL + CHB 3423 vs. 1887   68.0  73.3  0.77  [128]
                                                                      + 2403
                miR-122   Up      Serum  Single    Diagnosis HCC vs. CHB  71 vs. 45  77.6  57.8  0.63  [45]
                miR-122   Up      Serum  Single    Diagnosis HCC vs. HL  71 vs. 34  81.6  83.3   0.87  [45]
                miR-122   Down    Serum  Single    Diagnosis CH vs. HL  48 vs. 89  80.0   91.2   0.93  [46]
                miR-122   Down    Serum  Single    Diagnosis HCC vs. CHB  101 vs. 89  N/A  N/A   N/A  [46]
                miR-122   Up      Serum  Single    Diagnosis HCC vs. HL  101 vs. 89  70.7  69.1  0.79  [46]
                miR-122, let-7b Up  Serum  Multiple  Diagnosis HCC vs. HBV-  30 vs. 47  84.8  50.0  0.65  [129]
                                                          related DN
                miR-122, miR-     Plasma  Multiple  Diagnosis HCC vs. HL (V)  196 vs. 66  83.2  93.9  0.94  [49]
                192, miR-21,
                miR-223, miR-
                26a, miR-27a
                and miR-801
                miR-122, miR-     Plasma  Multiple  Diagnosis HCC vs. CHB (V) 196 vs. 72  79.1  76.4  0.84  [49]
                192, miR-21,
                miR-223, miR-
                26a, miR-27a
                and miR-802
                miR-122, miR-     Plasma  Multiple  Diagnosis HCC vs. LC (V)  196 vs. 56   75.0  91.1  0.88  [49]
                192, miR-21,
                miR-223, miR-
                26a, miR-27a
                and miR-803
                miR-122, miR-     Serum  Multiple +   Diagnosis HCC vs. LC  192 vs. 96  N/A   N/A  0.98  [60]
                885-5p, miR-             AFP
                221, miR-181b
                miR-122, miR-     Serum  Multiple  Diagnosis HCC vs. LC  192 vs. 96  N/A   N/A   0.84  [60]
                885-5p, miR-
                221, miR-181b
                miR-122, miR-     Serum  Multiple +   Diagnosis HCC vs. HL  192 vs. 96  N/A   N/A  1  [60]
                885-5p, miR-             AFP
                29b
                miR-122, miR-     Serum  Multiple  Diagnosis HCC vs. HL  192 vs. 96  N/A   N/A   0.89  [60]
                885-5p, miR-
                29b
                miR-122-5p  Up    Plasma  Single   Diagnosis CHB vs. HL  20 vs. 24  N/A    N/A   N/A    [43]
                miR-122-5p  Up    Plasma  Single   Diagnosis HCC vs. HL   20 vs. 28  N/A   N/A   N/A    [43]
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