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Page 8 of 22                                       Guerriero et al. Hepatoma Res 2019;5:6  I  http://dx.doi.org/10.20517/2394-5079.2018.108


                miR-122-5p  Up    Plasma  Single   Diagnosis LC vs. HL   20 vs. 22  N/A    N/A   N/A    [43]
                miR-122-5p  Up    Plasma  Single   Diagnosis HCC vs. HL + LC  7 vs. 14 + 21  N/A   N/A  N/A    [51]
                miR-122-5p  Up    Serum  Single    Diagnosis HCC vs. LC   24 vs. 14  N/A   N/A   N/A    [51]
                miR-122a  Down    Serum  Single    Diagnosis HCC vs. HL  85 vs. 85  70.6  67.1   0.71  [130]
                miR-122a  Down    Serum  Single + AFP  Diagnosis HCC vs. HL  85 vs. 85  87.1  98.8  0.94  [130]
                miR-1247-3p  Up   Serum   Single   Diagnosis HCC vs. HL  110 vs. 25  N/A   N/A   N/A    [131]
                miR-125a-5p   Down  Serum  Single  Diagnosis HCC vs. HL + CHB  120 vs. 164 +   N/A   N/A  N/A    [76]
                                                                      91
                miR-125b  Down    Plasma  Single   Diagnosis HCC vs. CHB  64 vs. 63  93.8  85.7  0.96  [58]
                miR-125b  Down    Plasma  Single   Diagnosis HCC vs. HL  64 vs. 56  85.9  78.6   0.89  [58]
                miR-125b  Down    Plasma  Single   Diagnosis HCC vs. LC  64 vs. 59  89.1  88.1   0.96  [58]
                miR-125b, miR- Down  Serum  Multiple +   Diagnosis HCC vs. HL   90 vs. 60  N/A  N/A  0.87  [50]
                223, miR-27a,            AFP
                and miR-26a
                miR-125b, miR- Down  Serum  Multiple +   Diagnosis HCC vs. HL   90 vs. 60  80.0  87.2  N/A     [50]
                27a                      AFP
                miR-125b-5p  Up   Plasma  Single   Diagnosis CHB vs. HL  20 vs. 24  N/A    N/A   N/A    [43]
                miR-125b-5p  Up   Plasma  Single   Diagnosis HCC vs. HL   20 vs. 28  N/A   N/A   N/A    [43]
                miR-125b-5p  Up   Plasma  Single   Diagnosis LC vs. HL   20 vs. 22  N/A    N/A   N/A    [43]
                miR-143   Down    Serum  Single    Diagnosis HCC vs. HL  131 vs. 122  80.3  82.4   0.83  [132]
                miR-145   Down    Serum  Single    Diagnosis HCC vs. CHB  85 vs. 50  88.2  78.0  0.85  [133]
                miR-148a  Down    Serum  Single    Diagnosis HCC vs. HL + BLD 76 vs. 55 + 62  67.7  59.2  0.67  [71]
                miR-148a, miR- Down  Serum  Multiple  Diagnosis HCC vs. BLD  76 vs. 62  96.1  91.9  0.94  [71]
                148b, miR-152
                miR-15b   Up      Serum  Single    Diagnosis HCC vs. HL + CHB 57 vs. 30 + 29  98.3  15.3  0.49  [124]
                miR-15b, miR-  Up  Serum  Multiple  Diagnosis HCC vs. HL + CHB 57 vs. 30 + 29  98.3  91.5  0.98  [124]
                130b
                miR-16    Down    Serum  Single + AFP  Diagnosis HCC vs. HL + CLD  105 vs. 71 +   92.4  78.5  N/A     [134]
                                                                      107
                miR-16, miR-      Serum  Multiple  Diagnosis HCC vs. HL + CLD  105 vs. 71 +   N/A   N/A  N/A    [134]
                195, miR-199a                                         107
                miR-18, miR-  Up  Exosomes Single  Diagnosis HCC vs. LC  20 vs. 20    N/A   N/A  N/A    [127]
                221, miR-222,
                miR-224
                miR-18, miR-  Up  Exosomes Single  Diagnosis HCC vs. CHB + LC 20 vs. 20 + 20    N/A   N/A  N/A    [127]
                221, miR-222,
                miR-224
                miR-182   Up      Serum  Single + AFP  Diagnosis HCC vs. HL + BLD 103 vs. 40 +   82.5  94.7     [135]
                                                                      95
                miR-182   Up      Serum  Single    Diagnosis HCC vs. HL + BLD 103 vs. 40 +   78.6  91.6  0.91  [135]
                                                                      95
                miR-182, miR-     Serum  Multiple +   Diagnosis HCC vs. HL + BLD 103 vs. 40 +   93.2  95.8  N/A  [135]
                331-3p                   AFP                          95
                miR-192-5p  Up    Serum  Single    Diagnosis HCC vs. HL + LC  74 vs. 60 + 43  N/A   N/A  0.69  [125]
                                                          (T)
                miR-192-5p   Up   Serum  Single    Diagnosis HCC vs. HL (T)  50 vs. 50  N/A   N/A  N/A    [125]
                and miR-29a-
                3p
                miR-192-5p   Up   Serum  Single    Diagnosis HCC vs. HL (V)  100 vs. 70  N/A   N/A  N/A    [125]
                and miR-29a-
                3p
                miR-199a  Down    Serum  Single    Diagnosis HCC vs. CH   23 vs. 17  54.5  100   0.85  [136]
                miR-21    Up      Serum  Single    Diagnosis HCC vs. CH    23 vs. 17  100  82.1  0.94  [136]
                miR-21    Up      Serum  Single    Diagnosis CHC vs. HL  62 vs. 19  87.1  73.7   0.83  [137]
                miR-21    Up      Serum  Single    Diagnosis HCC vs. HL  29 vs. 19  N/A   N/A    N/A  [137]
                miR-21    Up      Serum  Single    Diagnosis   HCC vs. LC (V)  175 vs. 78  80.8  72.9  0.81  [59]
                miR-21    Up      Serum  Single    Diagnosis   HCC vs. CHB (V) 175 vs. 64  76.9  85.7  0.79  [59]
                miR-21    Up      Serum  Single    Diagnosis   HCC vs. HL (T)  40 vs. 40             [59]
                miR-21    Up      Serum  Single    Diagnosis   HCC vs. HL + CHB  175 vs. 136 +   82.1  83.9  0.85  [59]
                                                          + LC (V)    64 + 78
                miR-21    Up             Single    Diagnosis HCC vs. HL + CHB 3423 vs. 1887   86.6  79.5  0.88  [128]
                                                                      + 2403
                miR-21    Down    Serum  Single    Diagnosis HCC vs. HL  70 vs. 34  N/A   N/A    N/A  [45]
                miR-21    Up      Plasma  Single + AFP  Diagnosis HCC vs. HL + CH                                              127 vs. 50 +   90.0  92.9  0.82  [48]
                                                                      30
                miR-21    Up      Plasma  Single   Diagnosis HCC vs. HL + CH                                              126 vs. 50 +   61.1  83.3  0.77  [48]
                                                                      30
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