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Page 14 of 22                                       Guerriero et al. Hepatoma Res 2019;5:6  I  http://dx.doi.org/10.20517/2394-5079.2018.108


               Table 5. Circulating long noncoding RNAs as biomarkers of hepatocellular carcinoma
                lncRNA           Expression Body fluid Experimental setting  Clinical setting  Cohorts comparison  Ref.
                AF085935            Up     Serum    Single         Diagnosis (early)  HCC vs. HL     [95]
                AF085935            Up     Serum    Single         Diagnosis (early)  HCC vs. HBV carriers    [95]
                CTBP + LAMP2 + miR-16-2      Serum  Multiple + miRNA   Diagnosis  HCC vs. HL + CHC   [153]
                + miR-21-5p
                CTBP + LAMP2 + miR-16-2      Serum  Multiple + miRNA   Prognosis (PFS)  HCC          [153]
                + miR-21-5p
                DANCR               Up     Plasma   Single         Diagnosis     HCC vs. HL + CHB + LC  [105]
                DANCR               Up     Plasma   Single         Prognosis     HCC                 [105]
                ENSG00000258332.1 +   Up   Serum    Multiple + AFP  Diagnosis    HCC vs. HL + LC + CHB  [96]
                LINC00635
                ENSG00000258332.1 +   Up   Serum    Single         Prognosis (OS)  HCC               [96]
                LINC00635
                HULC                Up     Plasma   Single         Diagnosis     HCC vs. HL          [104]
                HULC                Up     Plasma   Single         Diagnosis     HCC vs. HL          [154]
                HULC + LINC00152    Up     Plasma   Multiple + AFP  Diagnosis    HCC vs. HL          [104]
                JPX                 Down   Plasma   Single + AFP   Diagnosis     HCC vs. HL          [101]
                JPX                 Down   Plasma   Single         Diagnosis     HCC vs. HL          [101]
                JPX                 Down   Plasma   Single         Prognosis     HCC                 [101]
                JUN + UCA1          Up     Serum    Multiple       Diagnosis (early)  HCC vs. HL + CHC  [155]
                JUN + UCA1          Up     Serum    Multiple + AFP  Diagnosis (early)  HCC vs. HL + CHC  [155]
                LRB1                Up     Serum    Single + AFP/DCP  Diagnosis  HCC vs. HL          [102]
                LRB1                Up     Serum    Single          Prognosis (OS)  HCC              [102]
                LINC00152           Up     Plasma   Single         Diagnosis     HCC vs. HL          [104]
                LINC00974           Up     Plasma   Single         Diagnosis (early)  HCC vs. HL     [156]
                LINC01225           Up     Serum    Single         Diagnosis     HCC vs. HL          [157]
                lnc-PCDH9-13:1      Up     Saliva   Single         Diagnosis (early)  HCC vs. HL + HBV carrier   [107]
                                                                                 + CHB + LC
                LOC149086 + RP11-   Up     Plasma   Multiple       Diagnosis     HCC vs. cancer free (T)  [158]
                160H22.5 + XLOC_014172
                LOC149086 + RP11-   Up     Plasma   Multiple       Diagnosis     HCC vs. cancer free (V)  [158]
                160H22.5 + XLOC_014172
                PIVKAII + MALAT1    Up     Plasma   Multiple + AFP  Diagnosis    HCC vs. HL          [159]
                PVT1 + uc002mbe.2   Up     Serum    Multiple       Diagnosis     HCC vs. HL          [100]
                SNHG1               Up     Plasma   Single         Diagnosis     HCC vs. HL + CHB + LC  [97]
                SNHG1               Up     Plasma   Single + AFP   Diagnosis     HCC vs. HL + CHB + LC  [97]
                SPRY4-IT1           Up     Plasma   Single + AFP   Diagnosis     HCC vs. HL          [160]
                SPRY4-IT1           Up     Plasma   Single         Diagnosis     HCC vs. HL          [160]
                uc001ncr + AX800134        Serum    Multiple       Diagnosis (early)  HCC vs. HL + HBV carriers  [161]
                uc003wbd            Up     Serum    Single         Diagnosis (early)  HCC vs. HL     [95]
                uc003wbd            Up     Serum    Single         Diagnosis (early)  HCC vs. HBV carriers    [95]
                UCA1                Up     Serum    Single         Diagnosis     HCC vs. HL + CHC    [99]
                UCA1                Up     Serum    Single         Prognosis (PSF)  HCC              [103]
                UCA1 + WRAP53       Up     Serum    Multiple + AFP  Diagnosis    HCC vs. HL + CHC    [99]
                UCA1 + WRAP53       Up     Serum    Multiple       Diagnosis     HCC vs. HL + CHC    [99]
                WRAP53              Up     Serum    Single         Diagnosis     HCC vs. HL + CHC    [99]
                WRAP53              Up     Serum    Single         Prognosis (PSF)  HCC              [99]
                XIST                Down   Plasma   Single         Prognosis     HCC                 [101]
                ZFAS1               Up     Plasma   Single + AFP   Diagnosis     HCC vs. HL (T)      [98]
                ZFAS1               Up     Plasma   Single + AFP   Diagnosis     HCC vs. HL + CHB + LC (V)  [98]
                ZFAS1               Up     Plasma   Single         Diagnosis     HCC vs. HL (T)      [98]
                ZFAS1               Up     Plasma   Single         Diagnosis     HCC vs. HL + CHB + LC (V)  [98]
               lncRNA: long noncoding RNA; AFP: alpha fetoprotein; DCP: des-carboxyprothrombin; CHC: chronic hepatitis C; CHB: chronic hepatitis B;
               HBV: hepatitis B virus; HCC: hepatocellular carcinoma; HL: healthy liver; LC: liver cirrhosis; (T): training set; (V): validation set; OS: overall
               survival; PFS: progression free survival

               5p was decreased in non-responder patients compared to responders, suggesting this miRNA as a candidate
               serum biomarker for predicting response to sorafenib.
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