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Guerriero et al. Hepatoma Res 2019;5:6  I  http://dx.doi.org/10.20517/2394-5079.2018.108                                     Page 17 of 22


               Albeit often very exciting, results from the scientific literature are so far inconsistent. To change this status
               and open the way to translational applications, prospective well-designed large multicenter trials are needed.


               DECLARATIONS
               Authors’ contributions
               Conceived and designed the study: Callegari E, Sabbioni S, Negrini M
               Wrote the manuscript: Guerriero P, Moshiri F, Lupini L, Callegari E, Negrini M
               Read and approved the manuscript: All authors


               Availability of data and materials
               Not applicable.


               Financial support and sponsorship
               This work was supported by funds from the Italian Association for Cancer Research and from the University
               of Ferrara to Negrini M.

               Conflicts of interest
               All authors declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               Not applicable.


               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2019.


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