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Guerriero et al. Hepatoma Res 2019;5:6 I http://dx.doi.org/10.20517/2394-5079.2018.108 Page 17 of 22

Albeit often very exciting, results from the scientific literature are so far inconsistent. To change this status
and open the way to translational applications, prospective well-designed large multicenter trials are needed.

DECLARATIONS
Authors’ contributions
Conceived and designed the study: Callegari E, Sabbioni S, Negrini M
Wrote the manuscript: Guerriero P, Moshiri F, Lupini L, Callegari E, Negrini M
Read and approved the manuscript: All authors

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by funds from the Italian Association for Cancer Research and from the University
of Ferrara to Negrini M.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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