Page 55 - Read Online

Sun et al. Chem Synth 2023;3:16 https://dx.doi.org/10.20517/cs.2022.45 Page 13 of 17

Figure 7. Schematic illustration of (A) gene-photothermal synergistic therapy taking advantage of the host-guest interaction between
[72]
CB[7] and Ada (reproduced with permission from ref. , Copyright 2021, Chinese Chemical Society; This Figure has been published in
CCS Chemistry [2021]; [Supramolecular Vesicles Based on Gold Nanorods for Precise Control of Gene Therapy and Deferred
Photothermal Therapy] is available online at [10.31635/ccschem.021.202101029; https://www.chinesechemsoc.org/doi/full/
10.31635/ccschem.021.202101029]); (B) chemo-chemodynamic-photothermal synergistic therapy based on rP W and host-guest
18
2
interaction between CD and DOX (reproduced with permission from ref. [73] , Copyright 2022, American Chemical Society).
followed by the grafting of β-CD modified hyaluronic acid through host-guest interaction between DOX
and β-CD. The as-prepared rP W -based nanomaterials showed excellent photothermal behavior under
18
2
laser irradiation. In addition, upon tumor acidic microenvironment and laser irradiation, the host-guest
interaction was disrupted, followed by the release of DOX and initiation of chemotherapy. Moreover, the
rP W cluster was featured with the capability to reduce overexpressed oxidants at tumor sites, further
18
2
offering chemodynamic therapy.
CONCLUSION AND OUTLOOK
In summary, proved by the recent progress, it is safe to conclude that the host-guest interaction can be
taken as an efficient weapon for the improvement of photothermal cancer therapy. Through host-guest
interaction, the biocompatibility, stability and photothermal conversion efficiency of photothermal agents
can be optimized. In addition, upon the tumor microenvironment, the size switch of the host-guest