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Yang et al. Chem Synth 2023;3:7 https://dx.doi.org/10.20517/cs.2022.38 Page 11 of 54
Scheme 10. Organocascade three-component domino reaction of benzolactone-derived olefins 1, aldehydes 21 and α, β-unsaturated
aldehydes 22. This figure is used with permission from the Royal Society of Chemistry [50] .
Scheme 11. Organocascade Michael/Cyclization reaction of benzolactone-derived olefin 1 with α-isothiocyanato imide 24. This figure is
used with permission from John Wiley and Sons Ltd [53] .
butyrolactone/valerolactone moieties are present in many biologically active molecules and natural
products, as shown in Figure 1. To access this type of potentially bioactive compounds, the use of readily
available α, β-unsaturated butyrolactones/valerolactones 27 as dipolarophile synthons presents a promising
one [Scheme 12]. However, due to the inherent inertness of the α, β-unsaturated esters, the corresponding