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Page 6 of 9 Liu et al. Chem Synth 2023;3:22 https://dx.doi.org/10.20517/cs.2023.18
Scheme 2. Gram-scale Reaction and Product Derivatization. [a] Reaction conditions:1 (0.4 mmol), DDQ (0.44 mmol), H1 (0.6 mmol).
Ee was determined by chiral HPLC analysis. Isolated yield. The specified temperature for each example is for the second step
(reduction). [b] Run with 0.5 mol% of catalyst. [c] Run with 1 mol% of catalyst. [d] Run with 2 mol% of catalyst. [e] Run with 5 mol%
of catalyst.
