Page 81 - Read Online

Page 257 Nickoloff et al. Cancer Drug Resist 2021;4:244-63 I http://dx.doi.org/10.20517/cdr.2020.89

23. Croteau DL, Popuri V, Opresko PL, Bohr VA. Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem
2014;83:519-52.
24. Casper AM, Durkin SG, Arlt MF, Glover TW. Chromosomal instability at common fragile sites in Seckel syndrome. Am J Hum Genet
2004;75:654-60.
25. Gavande NS, VanderVere-Carozza PS, Hinshaw HD, et al. DNA repair targeted therapy: The past or future of cancer treatment?
Pharmacol Ther 2016;160:65-83.
26. Pearl LH, Schierz AC, Ward SE, Al-Lazikani B, Pearl FM. Therapeutic opportunities within the DNA damage response. Nat Rev Cancer
2015;15:166-80.
27. Nickoloff JA. Paths from DNA damage and signaling to genome rearrangements via homologous recombination. Mutat Res
2017;806:64-74.
28. Nickoloff JA, Boss MK, Allen CP, LaRue SM. Translational research in radiation-induced DNA damage signaling and repair. Transl
Cancer Res 2017;6:S875-S91.
29. Desai A, Yan Y, Gerson SL. Advances in therapeutic targeting of the DNA damage response in cancer. DNA Repair 2018;66-67:24-9.
30. Blackford AN, Jackson SP. ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response. Mol Cell 2017;66:801-17.
31. Hengel SR, Spies MA, Spies M. Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer
therapy. Cell Chem Biol 2017;24:1101-19.
32. Killock D. Targeted therapies: DNA polymerase theta-a new target for synthetic lethality? Nat Rev Clin Oncol 2015;12:125.
33. Pilie PG, Tang C, Mills GB, Yap TA. State-of-the-art strategies for targeting the DNA damage response in cancer. Nat Rev Clin Oncol
2019;16:81-104.
34. Carrassa L, Damia G. DNA damage response inhibitors: Mechanisms and potential applications in cancer therapy. Cancer Treat Rev
2017;60:139-51.
35. Nickoloff JA, Jones D, Lee S-H, Williamson EA, Hromas R. Drugging the cancers addicted to DNA repair. J Natl Cancer Inst
2017;109:djx059.
36. Yazinski SA, Zou L. Functions, regulation, and therapeutic implications of the ATR checkpoint pathway. Annu Rev Genet 2016;50:155-73.
37. Serrano MA, Li Z, Dangeti M, et al. DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous
recombination DNA repair. Oncogene 2013;32:2452-62.
38. Awasthi P, Foiani M, Kumar A. ATM and ATR signaling at a glance. J Cell Sci 2015;128:4255-62.
39. Weber AM, Ryan AJ. ATM and ATR as therapeutic targets in cancer. Pharmacol Ther 2015;149:124-38.
40. Williams RM, Yates LA, Zhang X. Structures and regulations of ATM and ATR, master kinases in genome integrity. Curr Opin Struct
Biol 2020;61:98-105.
41. Mordes DA, Cortez D. Activation of ATR and related PIKKs. Cell Cycle 2008;7:2809-12.
42. Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA
damage. Science 2007;316:1160-6.
43. Tapia-Alveal C, Calonge TM, O’Connell MJ. Regulation of Chk1. Cell Div 2009;4:8.
44. Merry C, Fu K, Wang J, Yeh IJ, Zhang Y. Targeting the checkpoint kinase Chk1 in cancer therapy. Cell Cycle 2010;9:279-83.
45. Smith J, Tho LM, Xu N, Gillespie DA. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res
2010;108:73-112.
46. Mladenov E, Magin S, Soni A, Iliakis G. DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and
cancer: Cell cycle and proliferation-dependent regulation. Semin Cancer Biol 2016;37-38:51-64.
47. Berti M, Vindigni A. Replication stress: getting back on track. Nat Struct Mol Biol 2016;23:103-9.
48. Branzei D, Foiani M. The checkpoint response to replication stress. DNA Repair 2009;8:1038-46.
49. Mazouzi A, Velimezi G, Loizou JI. DNA replication stress: causes, resolution and disease. Exp Cell Res 2014;329:85-93.
50. Zeman MK, Cimprich KA. Causes and consequences of replication stress. Nat Cell Biol 2014;16:2-9.
51. Chang HHY, Pannunzio NR, Adachi N, Lieber MR. Non-homologous DNA end joining and alternative pathways to double-strand break
repair. Nat Rev Mol Cell Biol 2017;18:495-506.
52. Wright WD, Shah SS, Heyer WD. Homologous recombination and the repair of DNA double-strand breaks. J Biol Chem
2018;293:10524-35.
53. de Koning AP, Gu W, Castoe TA, Batzer MA, Pollock DD. Repetitive elements may comprise over two-thirds of the human genome.
PLoS Genet 2011;7:e1002384.
54. Piazza A, Heyer WD. Homologous recombination and the formation of complex genomic rearrangements. Trends Cell Biol
2019;29:135-49.
55. Guirouilh-Barbat J, Lambert S, Bertrand P, Lopez BS. Is homologous recombination really an error-free process? Front Genet
2014;5:175.
56. Sfeir A, Symington LS. Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? Trends Biochem Sci
2015;40:701-14.
57. Costantino L, Sotiriou SK, Rantala JK, et al. Break-induced replication repair of damaged forks induces genomic duplications in human
cells. Science 2014;343:88-91.
58. Iliakis G, Murmann T, Soni A. Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous
end-joining and homologous recombination repair: Implications for the formation of chromosome translocations. Mutat Res Genet
Toxicol Environ Mutagen 2015;793:166-75.