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Xu et al. Cancer Drug Resist 2024;7:13 https://dx.doi.org/10.20517/cdr.2023.141 Page 5 of 14

Table 1. Summary of miRNAs currently bind to circRNAs in TNBC
Expression
CircRNAs MiRNAs Targets Functions Ref.xx
in TNBC
CircCRIM1 High miR-503-5p OGA/FBP1 Increases glycosylation hydrolase OGA and decreases FBP1 [37]
CircEGFR High miR-1299 EGFR Regulates malignant progression of TNBC by controlling EGFR [39]
through miR-1299, leading to THP drug-resistant
CircNCOR1 Low miR-638 CDK2 CircNCOR1 binds to hsa-miR-638 and targets CDK2 to regulate [42]
TNBC radio-sensitivity
CircFGFR4 High miR-185-5p CXCR4 CircFGFR4 exerts an impact on immune evasion and resistance [43]
to PD-1 immunotherapy through miR-185-5p/CXCR4 axis in TNBC
CircDUSP1 Low miR-761 DACT2 Reduces the suppression of DACT2 expression by miR-761 and [40]
thus increases the sensitivity of TNBC cells to paclitaxel
Circ-TRIO High miR-432-5p CCDC58 Circ-TRIO may regulate CCDC58 expression by combining [44]
with miR-432-5p
CircRAD54L2 High miR-888 PDK1 Regulates PDK1 expression by sponging the miR-888 family [45]
and PDK1
Circ0004676 High miR-377-3p E2F6/PNO1 Circ0004676 increases E2F6 and its target PNO1 expression [46]
by sponging miR-377-3p
CircCSNK1G1 High miR-28-5p LDHA Circ-CSNK1G1 represses miR-28-5p and positively regulates LDHA [47]
expression
CircUBR5 High miR-1179 UBR5 CircUBR5 upregulates UBR5 expression by suppressing miR-1179 [48]
CircDHDDS High miR-362-3p DDX5 CircDHDDS accelerates TNBC by upregulating DDX5 via [49]
miR-362-3p adaptation
CircPRKCI High miR-545-3p WBP2 and CircPRKCI acts as miR-545-3p sponge to regulate WBP2 and AKT [50]
PI3K/AKT phosphorylation
CircPTK2 Low miR-136 NFBI and CircPTK2 serves as miR-136 sponge and direct regulator of NFBI [51]
AKT/PI3K and AKT/PI3K pathways
CircUBAP2 High miR-300 ASF1B and PI3K/ CircUBAP2 upregulates ASF1B by miR-300, which triggers (PAM) [52]
AKT/mTOR signaling to increase DDP resistance in TNBC.
CircFAM64A High miR-149-5p CDT1 CircFAM64A sponges miR-149-5p to increase CDT1 expression and [53]
promote cellular processes in TNBC
CircCD44 High miR-502-5p KRAS and CircCD44 contributes to TNBC cell proliferation, migration, invasion, [54]
IGF2BP2/Myc and tumorigenesis, in part through miR-502-5p sponge activity and
interaction with IGF2BP2
Circ-PDCD11 High miR-432-5p LDHA By sponging up miR-432-5p, circPDCD11 enhances LDHA expression [55]
Circ-ERBB2 High miR-136-5p PDK4 As a result of miR-136-5p inhibition by circ-ERBB2, PDK4 expression [56]
is increased
CircWHSC1 High miR-212-5p AKT3 CircWHSC1 promotes malignancy and glycolysis in TNBC cells by [38]
sequestering miR-212-5p.
CircWAC High miR-142 WWP1 and CircWAC sponges miR-142 to elevate WWP1 expression and [57]
PI3K/AKT activate PI3K/AKT pathway
CircNR3C2 Low miR-513a-3p HRD1/ Overexpression of circNR3C2 significantly improves the tumor [58]
Vimentin suppressive effects of HRD1 by sponging miR-513a-3p
CircPSMA1 High miR-637 Akt1/β-catenin CircPSMA1 functions as a promoter of tumor growth through the [59]
(cyclin D1) circPSMA1/miR-637/Akt1-β-catenin (cyclin D1) regulatory pathway
CircBACH2 High miR-186-5p CXCR4 The expression of CXCR4 is increased, resulting from the [60]
/miR-548c-3p sponging of miR-186-5p and miR-548c-3p by ircBACH2
Circ_102229 High miR-152-3p PFTK1 Hsa_circ_102229 could regulate the expression of PFTK1 by [61]
targeting miR-152-3p
CircUBE2D2 High miR-512-3p CDCA3 CircUBE2D2 facilitates the advancement of TNBC and increases [41]
resistance to doxorubicin by functioning as a miR-512-3p sponge,
which results in elevated CDCA3 expression
Circ0000199 High miR-613 and PI3K/Akt/ Hsa_circ_0000199 improves sensitivity to chemotherapy in TNBC by [62]
miR-206 mTOR promoting the expression of miR-206/miR-613 and deactivating
PI3K/Akt/mTOR signaling pathway
CircIFI30 High miR-520b-3p CD44 CircIFI30 sponges miR-520b-3p, thus releasing the CD44 expression [63]
CircPGAP3 High miR-330-3p Myc Circ-PGAP3 promotes the development of TNBC cells by inhibiting [64]
miR-330-3p through its sponging function, leading to increased
gene expression of the proto-oncogene Myc
CircFBXW7 Low miR-197-3p FBXW7 FBXW7 gene sponges miR-197-3p and produces FBXW7-185aa [11]