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Special Topic Introduction

Scientific Background

Cancer drug resistance arises through complex and multifactorial mechanisms, including
genetic mutations, epigenetic alterations, tumor heterogeneity, and adaptive responses within
the tumor microenvironment. These factors collectively reduce treatment efficacy across
multiple therapeutic modalities.

Precision Medicine Perspective
Precision medicine provides a framework to address drug resistance through patient-specific

molecular profiling, enabling the identification of therapeutic vulnerabilities and personalized
treatment strategies.

Emerging Technologies
Recent advances in multi-omics technologies, nanomedicine, artificial intelligence, and

advanced imaging have significantly expanded our ability to investigate and target resistance
mechanisms at multiple biological levels.

Scope of the Special Topic

This Special Topic focuses on:
• Mechanisms of cancer drug resistance
• Molecular targets and signaling pathways
• Precision drug delivery strategies

• Nanomaterial-based therapeutic approaches
• Emerging technologies in resistance research

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