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Page 16 of 18                                                 Wang et al. Cancer Drug Resist. 2026;9:8




               DECLARATIONS
               Acknowledgments
               The graphical abstract was created with BioRender.com [Created in BioRender. Lingna, W. (2026) h​t​t​p​s​:​/​/​B​i
               o​R​e​n​d​e​r​.​c​o​m​/​p​6​o​6​g​u​9​]. We would like to thank Hanbo Zhang (Cixi Biomedical Research Institute,
               Wenzhou Medical University, China) for his constructive suggestions on the cell culture, and Dr. Zhengchun
               Wang (Ningbo University Health Science Center, China) for providing the HCC827/IR cells.

               Authors’ contributions
               Methodology, investigation, validation, formal analysis, and data curation: Wang L, Mao Y, Dong Y, Tan M,
               Wang X, Liu Z, Yuan H, Wang B
               Writing - original draft: Wang L, Mao Y, Dong Y
               Project administration, supervision, and writing - review and editing: Nie C, Xing S, Li M, Yuan H, Wang B
               Funding acquisition: Wang L, Xing S, Wang B
               All authors contributed significantly to this work.
               All authors have read and approved the final manuscript to be published.

               Availability of data and materials
               All datasets and materials generated in this study can be provided by the corresponding author (Bing Wang)
               upon reasonable request.


               AI and AI-assisted tools statement
               During the preparation of this manuscript, the AI tool DeepSeek (version V3.2, released 2025-12-01) was
               used solely for language editing. The tool did not influence the study design, data collection, analysis,
               interpretation, or the scientific content of the work. All authors take full responsibility for the accuracy,
               integrity, and final content of the manuscript.


               Financial support and sponsorship
               This work was supported by the National Natural Science Foundation of China (22107104, 22377132), the
               China Postdoctoral Science Foundation (2022M713245), Zhejiang Provincial Natural Science Foundation of
               China (LQ23H180001), and Ningbo Natural Science Foundation (2023J067).

               Conflicts of interest
               All authors declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2026.

               Supplementary Materials
               Supplementary Materials


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