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Table 2. Summary of genetically modified rabbits
System Genes Modification Application Refs.
ZFN IgM KO Immunodeficiency [48]
ZFN APOC3 KO Lipid metabolism and [49]
atherosclerosis
[50]
ZFN APOE KO Lipid metabolism and
atherosclerosis
[51]
ZFN CETP KO Lipid metabolism and
atherosclerosis
[52]
TALENs RAG1; RAG2 KO Immunodeficiency
[53]
TALENs FAH KO Hereditary tyrosinemia type 1
[54]
CRISPR/Cas9 FBN1 KO Marfanoid progeroid lipodystrophy syndrome
[55]
CRISPR/Cas9 DMD KO Duchenne muscular dystrophy
[56]
CRISPR/Cas9 ANO5 KO Muscular dystrophy
[57]
CRISPR/Cas9 α-Crystallin KO Congenital cataracts
[58]
CRISPR/Cas9 GJA8 KO Congenital cataracts
[59]
CRISPR/Cas9 LDLR KO Lipid metabolism and
atherosclerosis
[60,61]
CRISPR/Cas9 MSTN KO Muscle hypertrophy
[53,54]
CRISPR/Cas9 SRY KO Sex reversal syndromes and
hermaphroditism syndromes
[62]
CRISPR/Cas9 PHEX KO X-linked hypophosphatemia
[63]
CRISPR/Cas9 LMNA KO Premature aging syndrome
[64]
CRISPR/Cpf1 WRN KO Werner syndrome
[65,66]
CRISPR/Cas9 TYR KO Oculocutaneous albinism
[67]
CRISPR/Cas9 DMP1 KO Mineralization defects
[68]
CRISPR/Cas9 GADD45G KO Congenital cleft palate
[69]
CRISPR/Cas9 HOXC13 KO Hair and nail ectodermal dysplasia
[70]
CRISPR/Cas9 GCK KO Maturity-onset diabetes of the young type 2
[71]
CRISPR/Cas9 HBB2 KO β-thalassemia
[72]
CRISPR/Cas9 WAS KO Wiskott-Aldrich syndrome
[73]
CRISPR/Cas9 CBS KO Congenital hyper-homocysteinemia
[74]
CRISPR/Cas9 LDLR; APOE KO Lipid metabolism and
atherosclerosis
[75]
CRISPR/Cas9 APOC3 KO Lipid metabolism and
atherosclerosis
[76]
CRISPR/Cas9 CFTR KO Cystic fibrosis
[77]
CRISPR/Cas9 CFTR KO ΔF508 Cystic fibrosis
[69]
CRISPR/Cas9 CLPG KO Muscular hypertrophy syndrome
[78]
CRISPR/Cas9 FGF5 KO Long hair
[79]
CRISPR/Cas9 IL2RG KO X-linked severe combined
immunodeficiency
[80]
CRISPR/Cas9 MC1R KO Block the synthesis of eumelanin and create a novel pale-yellow coat
color
[73]
CRISPR/Cas9 XIST P1 KO X-chromosome inactivation
[74]
CRISPR/Cas9 MSTN KO Muscle hypertrophy
[75]
CRISPR/Cas9 PCSK9 p.S386A Lipid metabolism and
atherosclerosis
[81]
CRISPR/Cas9 ATP7B p. R778L Wilson Disease
[82]
CRISPR/Cas9 TYR p. T373K Oculocutaneous albinism
[83]
CRISPR/Cas9 TYR KO Oculocutaneous albinism
[84-86]
CRISPR/Cas9 RAG; RAG2; TIKI1; ALB; Multiplex gene KO Immunodeficiency
IL2RG
CRISPR/Cas9 FUT1; FUT2; SEC1 KO Fucosyltransferases enzymes activity [87]