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De Robertis et al. Art Int Surg 2023;3:166-79 Artificial
DOI: 10.20517/ais.2023.18
Intelligence Surgery

Review Open Access

The role of radiomics in hepato-bilio-pancreatic
surgery: a literature review

Riccardo De Robertis , Marco Todesco, Daniele Autelitano, Flavio Spoto, Mirko D’Onofrio

Department of Radiology, Ospedale G.B. Rossi-University of Verona, Verona 37134, Italy.
Correspondence to: Dr. Riccardo De Robertis, Department of Radiology, Ospedale G.B. Rossi-University of Verona, Piazzale L.A.
Scuro 10, Verona 37134, Italy. E-mail: riccardo.derobertislombardi@univr.it

How to cite this article: De Robertis R, Todesco M, Autelitano D, Spoto F, D’Onofrio M. The role of radiomics in hepato-bilio-
pancreatic surgery: a literature review. Art Int Surg 2023;3:166-79. https://dx.doi.org/10.20517/ais.2023.18

Received: 19 May 2023 First Decision: 25 Jul 2023 Revised: 30 Jul 2023 Accepted: 7 Sep 2023 Published: 11 Sep 2023

Academic Editors: Nikdokht Rashidian, Andrew A. Gumbs Copy Editor: Pei-Yun Wang Production Editor: Pei-Yun Wang

Abstract
Radiomics is an advanced computational analysis of biomedical images that aims to obtain a detailed, objective,
and multidimensional characterization of biological tissues. Radiomics features ultimately represent the
physiopathology of the tissue under study and can be used to characterize and quantify the spatial distribution and
interactions between the voxels that compose a biomedical image. The aim of this paper was to review the current
role of radiomics in hepato-bilio-pancreatic surgery by analyzing systematic reviews, meta-analyses and the most
relevant published series. Literature data revealed that radiomics is a promising tool in improving the non-invasive
characterization and preoperative staging of hepato-bilio-pancreatic neoplasms. Nevertheless, there are major
limitations in this approach, mainly linked to the lack of standardization in image acquisition, that result in a
significant translational gap between research and clinical practice.

Keywords: Radiomics, liver, pancreas, bile ducts, computed tomography, magnetic resonance imaging

INTRODUCTION
Hepato-bilio-pancreatic (HBP) surgery comprises demanding and complex procedures, the planning of
which requires highly specific radiological skills for diagnosis, staging, and evaluation of treatment response.
The interpretation of imaging results, in view of the clinical findings, relies heavily on the training and
experience of the radiologist; as such, the conventional process of image interpretation has limited

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
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indicate if changes were made.

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