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Skoreński et al. Rare Dis Orphan Drugs J 2023;2:6  https://dx.doi.org/10.20517/rdodj.2022.21  Page 7 of 23



















                                           Figure 6. Structures of covalent HNE inhibitors [39,40] .
















                                            Figure 7. Structure of competitive HNE inhibitor [41] .













                                      Figure 8. Structures of non-competitive allosteric HNE inhibitor [42] .
























                                           Figure 9. Structures of oxo-β-lactam HNE inhibitors [43] .
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