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Wang et al. Microstructures 2023;3:2023042 Microstructures
DOI: 10.20517/microstructures.2023.46

Research Article Open Access

Influence of hydrogel and porous scaffold on the

magnetic thermal property and anticancer effect of
Fe O nanoparticles
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Man Wang , Rui Sun , Huajian Chen , Xiaohan Liu , Toru Yoshitomi , Masaki Takeguchi , Naoki
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Kawazoe , Yingnan Yang , Guoping Chen 1,2
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Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Ibaraki 305-0044, Japan.
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Subprogram in Materials Science and Engineering, Doctoral Program in Engineering Sciences, Graduate School of Science and
Technology, University of Tsukuba, Ibaraki 305-8577, Japan.
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Center for Basic Research on Materials, National Institute for Materials Science, Ibaraki 305-0044, Japan.
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Graduate School of Life and Environmental Science, University of Tsukuba, Ibaraki 305-8572, Japan.
Correspondence to: Prof./Dr. Guoping Chen, Research Center for Macromolecules and Biomaterials, National Institute for
Materials Science, Ibaraki 305-0044, Japan. E-mail: Guoping.CHEN@nims.go.jp
How to cite this article: Wang M, Sun R, Chen H, Liu X, Yoshitomi T, Takeguchi M, Kawazoe N, Yang Y, Chen G. Influence of
hydrogel and porous scaffold on the magnetic thermal property and anticancer effect of Fe O nanoparticles. Microstructures
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2023;3:2023042. https://dx.doi.org/10.20517/microstructures.2023.46
Received: 5 Sep 2023 First Decision: 20 Sep 2023 Revised: 27 Sep 2023 Accepted: 19 Oct 2023 Published: 10 Nov 2023
Academic Editors: Yin Xiao, Chun-Xia Zhao Copy Editor: Fangyuan Liu Production Editor: Fangyuan Liu
Abstract
Magnetic hyperthermia uses magnetic nanoparticles (MNPs) for conversion of magnetic energy into thermal
energy under an alternating magnetic field (AMF) to increase local temperature for ablation of cancer cells. The
magnetic thermal capacity of MNPs not only depends on the intrinsic properties of MNPs but is also affected by
the microenvironmental matrices surrounding the MNPs. In this study, the influence of agarose hydrogels and
gelatin porous scaffolds on the magnetic thermal property and anticancer effect of Fe O nanoparticles (NPs) were
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investigated with a comparison to free Fe O NPs. Flower-like Fe O NPs were synthesized and embedded in
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agarose hydrogels and gelatin porous scaffolds. Under AMF irradiation, the free Fe O NPs had the best magnetic
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thermal properties and the most efficiently increased the local temperature to ablate breast cancer cells. However,
the Fe O NPs embedded in agarose hydrogels and gelatin porous scaffolds showed reduced magnetic-thermal
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conversion capacity, and the local temperature change was decreased in comparison to free Fe O NPs during AMF
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irradiation. The gelatin porous scaffolds showed a higher inhibitory influence than the agarose hydrogels. The
inhibitory effect of agarose hydrogels and gelatin porous scaffolds on magnetic-thermal conversion capacity
resulted in a decreased anticancer ablation capacity to breast cancer cells during AMF irradiation. The Fe O NP-
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embedded gelatin scaffolds showed the lowest anticancer effect. The results suggested that the matrices used to
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