Page 83 - Read Online
P. 83

Page 4 of 4                                                        Ludwig et al. Vessel Plus 2020;4:8  I  http://dx.doi.org/10.20517/2574-1209.2019.37

               Financial support and sponsorship
               This work was supported by National Institutes of Health grants HL109002, DK091190, HL069846,
               DK068575, and DK079307 to EKJ and the NIH grant R01-CA 1686288 to TLW. NL was supported by the
               Leopoldina Fellowships LPDS 2017-12 and LPDR 2019-02 from German National Academy of Sciences
               Leopoldina.


               Conflicts of interest
               All authors declared that there are no conflicts of interest.


               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.


               Copyright
               © The Author(s) 2020.

               REFERENCES
               1.   Whiteside TL. Tumor-derived exosomes and their role in cancer progression. Adv Clin Chem 2016;74:103-41.
               2.   Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, et al. Glioblastoma microvesicles transport RNA and proteins that promote
                   tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10:1470-6.
               3.   Ludwig N, Whiteside TL. Potential roles of tumor-derived exosomes in angiogenesis. Expert Opin Ther Targets 2018;22:409-17.
               4.   Ludwig N, Yerneni SS, Razzo BM, Whiteside TL. Exosomes from HNSCC promote angiogenesis through reprogramming of endothelial
                   cells. Mol Cancer Res 2018;16:1798-808.
               5.   Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles 2014;3.
               6.   Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene
                   2013;32:2747-55.
               7.   Cai Y, Feng L, Wang X. Targeting the tumor promoting effects of adenosine in chronic lymphocytic leukemia. Crit Rev Oncol Hematol
                   2018;126:24-31.
               8.   Ethier MF, Chander V, Dobson JG Jr. Adenosine stimulates proliferation of human endothelial cells in culture. Am J Physiol
                   1993;265:H131-8.
               9.   Adair TH. Growth regulation of the vascular system: an emerging role for adenosine. Am J Physiol Regul Integr Comp Physiol
                   2005;289:R283-96.
               10.  Adair TH, Cotten R, Gu JW, Pryor JS, Bennett KR, et al. Adenosine infusion increases plasma levels of VEGF in humans. BMC Physiol
                   2005;5:10.
               11.  Azambuja JH, Ludwig N, Braganhol E, Whiteside TL. Inhibition of the Adenosinergic Pathway in Cancer Rejuvenates Innate and
                   Adaptive Immunity. Int J Mol Sci 2019;20:5698.
               12.  Dubey RK, Gillespie DG, Jackson EK. A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells.
                   Hypertension 2002;39:530-5.
               13.  Du X, Ou X, Song T, Zhang W, Cong F, et al. Adenosine A2B receptor stimulates angiogenesis by inducing VEGF and eNOS in human
                   microvascular endothelial cells. Exp Biol Med (Maywood) 2015;240:1472-9.
               14.  Auchampach JA. Adenosine receptors and angiogenesis. Circ Res 2007;101:1075-7.
               15.  Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between
                   A2B and A3 adenosine receptors. Circ Res 2003;92:485-92.
               16.  Ernens I, Bousquenaud M, Lenoir B, Devaux Y, Wagner DR. Adenosine stimulates angiogenesis by up-regulating production of
                   thrombospondin-1 by macrophages. J Leukoc Biol 2015;97:9-18.
               17.  Clark AN, Youkey R, Liu X, Jia L, Blatt R, et al. A1 adenosine receptor activation promotes angiogenesis and release of VEGF from
                   monocytes. Circ Res 2007;101:1130-8.
               18.  Schuler PJ, Saze Z, Hong CS, Muller L, Gillespie DG, et al. Human CD4+ CD39+ regulatory T cells produce adenosine upon co-
                   expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells. Clin Exp Immunol 2014;177:531-43.
               19.  Clayton A, Al-Taei S, Webber J, Mason MD, Tabi Z. Cancer exosomes express CD39 and CD73, which suppress T cells through
                   adenosine production. J Immunol 2011;187:676-83.
               20.  Sayner SL, Choi CS, Maulucci ME, Ramila KC, Zhou C, et al. Extracellular vesicles: another compartment for the second messenger,
                   cyclic adenosine monophosphate. Am J Physiol Lung Cell Mol Physiol 2019;316:L691-700.
   78   79   80   81   82   83   84   85   86   87   88