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Scullen et al. Vessel Plus 2020;4:9 Vessel Plus
DOI: 10.20517/2574-1209.2020.07

Editorial Open Access

Advancing the care of patients with cerebrovascular
disease: editorial

Tyler Scullen, Aaron S. Dumont

Department of Neurological Surgery, Tulane University, New Orleans, LA 70112, USA.
Correspondence to: Prof. Aaron S. Dumont, Department of Neurological Surgery, Tulane University, 131 South Robertson Street,
Suite 1300, New Orleans, LA 70112, USA. E-mail: adumont2@tulane.edu

How to cite this article: Scullen T, Dumont AS. Advancing the care of patients with cerebrovascular disease: editorial. Vessel Plus
2020;4:9. http://dx.doi.org/10.20517/2574-1209.2020.07

Received: 4 Feb 2020 Accepted: 24 Feb 2020 Published: 10 Apr 2020
Science Editor: Alexander D. Verin Copy Editor: Jing-Wen Zhang Production Editor: Jing Yu

Contemporary understanding of cerebrovascular disease has seen rapid development coupled with
translational clinical advancements. Increased knowledge of the basic processes of the disease has provided
Received: First Decision: Revised: Accepted: Published: x the basis for significant developments in the detection, prevention, and treatment of focal and systemic

Science Editor: Copy Editor: Production Editor: Jing Yu conditions whose combined effects present a disproportionately high burden on the health care system,
associate with multiple significant co-morbidities, and often carry high and protracted morbidity and
[1]
mortality . Such trends have been the result of an increased progressive and coordinated effort in various
related basic science and clinical fields. In this editorial, we review some important examples of the work
providing multidisciplinary contributions to the understanding and treatment of Cerebrovascular Disease,
as featured in this special issue.

Critical to the development of effective prevention and treatment strategies is an advanced understanding
[2]
of underlying disease pathophysiology and molecular biology. Accordingly, Padarti et al. provided a
comprehensive and well written review on the epidemiology, cellular biology, and phenotypic expression
of cerebral cavernous malformations (CCM) in the context of known CCM proteins. The article effectively
describes disease biology in a stepwise fashion following a brief summary on present epidemiology and
[2]
clinical presentation . Current understanding of the structural biology and genotype of each individual
implicated protein complex is provided prior to a discussion on consequent epigenetic processes and
[2]
inter- and intracellular interactions . A thoughtful review of possible mechanisms of disease is then
presented, supported by current in vitro and in vivo data and anecdotal evidence . Together, the authors
[2]
provided a succinct and comprehensive report on our modern understanding of CCM pathobiology and
suggested potential routes of future investigation. Such reviews are a vital substrate in the development of

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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