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Dastidar et al. Vessel Plus 2020;4:14 I http://dx.doi.org/10.20517/2574-1209.2019.36 Page 13 of 29
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In vivo: BALB/c mice bearing 4T1 tumours Ex vivo: C6 glioma cell In vivo: C6 tumour bearing nude mice Ex vivo: human breast cancer cell lines (MCF-7 and MDA-MB-231) Ex vivo: BJ cells and mouse fibroblast (NIH 3T3) cells Ex-vivo: human colorectal cell line (HCT116, SW620, and RKO) In vivo: a special strain of Balb/C mice bearing subcutaneous tumour Ex vivo: pancreatic cancer cell lines (AsPC- 1, PANC-1, and MIA Paca-2) In vivo: orthotropic model
tyrosine kinase associated with VEGF and Laser activated release of sunitinib inhibits Ex-vivo: 4T1 cell line PDGF receptors, whereas IR780 dye kills cancer cells by hyperthermia Drugs were released at the tumour microenvironment (low pH, presence of MMP). Sunitinib inhibits angiogenesis and the tumour matrix. Sunitinib was loaded in paclitaxel arrests cancer cells at the G2/M phase Gold nanoparticle delivers the peptide within the cell, where
Paclitaxel loaded pH-responsive micelle was coated with β-cyclodextrin via MMP- 2 sensitive peptide that was cleavable in Gold NP capped with monocarboxy (1-mercaptoundec-11-yl) hexa (ethylene Cetuximab conjugated paclitaxel loaded “2 in 1” nanoconjugates containing both cetuximab and gemcitabine on a single Polylactide-co-poly-(ethylene glycol) filomicelles of 100 nm length and spherical protein. Paclitaxel arrests cells at G2/M micel
Liposome this cyclodextrin layer glycol) FGF1 conjugated gold nanoparticle nanodiamond gold nanoparticle core Liposome as oral gavage nanoparticle micelles
Near-Infrared dye-IR780 Paclitaxel Gold nanoparticle Gold nanoparticle (AuNP) Paclitaxel Gemcitabine Paclitaxel Paclitaxel DOX Gemcitabine Not applicable Paclitaxel
Sunitinib Sunitinib KATWLPPR peptide FGF1 (recombinant ligand for all FGFRs) Cetuximab Cetuximab Lapatinib Lapatinib Gefitinib Gefitinib Erlotinib and Fedratinib Lapatinib
VEGF FGF Epidermal growth factor
