Page 158 - Read Online

Dastidar et al. Vessel Plus 2020;4:14 I http://dx.doi.org/10.20517/2574-1209.2019.36 Page 5 of 29

Vessel maintenance √

Endothelial assembly and lumen acquisition √ √

Maturation

Deposition of basement membrane √ √

Attachment of pericytes √ √

Adaptation to tissue needs Regression of neovessels due to lack of flow or presence of growth factors √

Functions

Neovessel formation Pericyte Endothelial cell proliferation proliferation and migration and migration √ √ √ √ √ √ √ √ √ √ √ √ √ VEGF: vascular endothelial growth factor; FGF: fibroblast growth factor; PDGFB: platelet-derived growth factor subunit B; PLGF: placental growth factor; THBS 1: thrombospondin 1; SDF1: stromal cell- derived factor 1; DLL1-4: delta like1-4 (notch ligands); SCF: stem cell factor; Ang-1: angiopoietin-1; CXXR

Table 1. List of angiogenic factors, corresponding receptors, and functions

Initiation of angiogenesis Enhancement Detachment Degradation of basement of vascular of pericytes membrane permeability √ √ √ √ √

Receptors VEGFR1 (Flt1) VEGFR2 (Kdr) Tie2 FGFR PDGFR VEGFR1 (Flt1) CD36, CD47, Integrins Extracellular matrix CXCR4 Notch cKit Interleukin receptors Tie2 platelet-derived growth factor receptor microcirculation region; and (4) advancing front.

Antigenic molecules VEGF Ang-2 FGF PDGFB PLGF THBS 1 Integrins SDF1 DLL1-4 SCF Interleukins Ang-1