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Page 4 of 29                                                  Dastidar et al. Vessel Plus 2020;4:14  I  http://dx.doi.org/10.20517/2574-1209.2019.36
















































































               Figure 2. Cell signalling pathways of hypoxia-induced tumour angiogenesis. MNK: mitogen-activated protein kinase interacting
               protein kinases; EGFR: endothelial growth factor; VEGFR2: vascular endothelial growth factor receptor type 2; PDGFR: platelet derived
               growth factor receptor; VEGF: vascular endothelial growth factor; ECM: extracellular matrix; MMP: matrix metalloproteinase; mTOR:
               mammalian target of rapamycin; TCEB: transcription elongation factor B; FGFR: fibroblast growth factor receptor; IGFR: insulin-like
               growth factor receptor
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