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Zlatkina et al. Vessel Plus 2019;3:7 I http://dx.doi.org/10.20517/2574-1209.2019.03 Page 3 of 11

[9]
Figure 1. The effect of insulin and glucose on the regulation of gene expression . IRS1/IRS2: insulin receptor substrates 1 and 2; Akt1:
proteinase B; PI3K: phosphatidylinositol-3-kinase; SREBP-1c: sterol-regulated element-binding protein 1C; FAS: fatty acid synthase; FOXO:
transcription factors; Glut4: glucose transporter; GK: glucokinase; L-PK: liver pyruvate kinase; S14: spot 14; G6P: glucose-6-phosphate

[11]
Figure 2. Schematic representation of the proximal area of the insulin 2 promoter in rats . C1 (RIRE3b1): promoter node; BETA2 (NeuroD):
transcription factor; PDX-1 (IDX-1/STF-1/IPF1): pancreatic/duodenal homeobox-1
elements, which are involved into activation in vitro [Figure 2].

Insulin promoter factor (PDX-1) also works with proteins of the basic dimerization transcription factors