Page 65 - Read Online

Zsíros et al. Vessel Plus 2019;3:6 I http://dx.doi.org/10.20517/2574-1209.2018.78 Page 5 of 6

Regular check-up is highly recommended after delivery, during lactation and especially during subsequent
pregnancies. Close cooperation between endocrinologist or lipid specialist and gynaecologist is also
necessary. With the exception of lipoprotein lipase deficiency, primary hypertriglyceridemia disorders
usually present in adulthood. Indeed, dozens of causative genetic abnormalities were described in severe
hypertriglyceridemia. Genetic testing is available for suspected cases of familial chylomicronemia syndrome
[5]
and dysbetalipo-proteinemia, but is not necessary for treatment . Still, sequencing of candidate genes may
help to guide future individualized therapeutic strategies in order to prevent further complications and to
identify affected relatives using cascade screening.

In case of significantly increased values, plasmapheresis is a fast, effective and safe method for decreasing
triglyceride level even in late pregnancy. However, multicentre, prospective studies including a larger
number of participants are required to support the observations and to define novel therapeutic guidelines.

DECLARATIONS
Authors’ contributions
Collection of data: Zsíros N, Harangi M
Analysis and/or interpretation of data: Zsíros N, Harangi M
Writing (not revising) all or sections of the manuscript: Zsíros N
Manuscript review: Kovács B, Harangi M
Supervision: Paragh G, Balla J
Study design: Paragh G, Harangi M

Availability of data and materials
The clinical and laboratory data used to support the findings of this work are included within the article.

Financial support and sponsorship
This research was supported by the GINOP-2.3.2-15-2016-00005 project. The project is co-financed by the
European Union under the European Regional Development Fund.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Informed consent was obtained from the patient after the approval of the local ethics committee.

Consent for publication
Informed consent was obtained from the patient.

Copyright
© The Author(s) 2019.

REFERENCES
1. Butte NF. Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr
2000;71:1256S-61.
2. Herrera E, Amusquivar E, López-Soldado I, Ortega H. Maternal lipid metabolism and placental lipid transfer. Horm Res 2006;65:59-64.
3. Brizzi P, Tonolo G, Esposito F, Puddu L, Dessole S, et al. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynecol
1999;181:430-4.
4. Knopp RH, Warth MR, Charles D, Childs M, Li JR, et al. Lipoprotein metabolism in pregnancy, fat transport to the fetus, and the effects
of diabetes. Biol Neonate 1986;50:297-317.