Page 385 - Read Online

Pal et al. Vessel Plus 2019;3:39 I http://dx.doi.org/10.20517/2574-1209.2019.24 Page 5 of 6

skilled interventional cardiologist. Once completed, RESHAPE-HF-2 (NCT02444338) should better define
the role of transcatheter edge-to-edge repair of secondary MR. Finally, we eagerly await longer term studies
that assess repair durability, compare different clip designs, and refine optimal medical management of
patients before and after percutaneous repairs.

DECLARATIONS
Acknowledgments
Sincere gratitude to Dr. Zachary Gertz, Director Interventional Cardiology, VCU Health System,
Richmond, Virginia for his inputs on revising the manuscript.

Authors’ contributions
Design, content, datacollection, literature search, discussion, inferences: Pal N
Design, content, discussion, inferences: Nelson M
Content, discussion, inferences, language ammendments: Butterworth J

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

REFERENCES
1. Kron IL, Acker MA, Adams DH, Ailawadi G, Bolling SF, et al; American Association for Thoracic Surgery Ischemic Mitral
Regurgitation Consensus Guidelines Writing Committee. 2015 The American Association for Thoracic Surgery Consensus
Guidelines: Ischemic mitral valve regurgitation. J Thorac Cardiovasc Surg 2016;151:940-56.
2. Feldman T, Foster E, Glower DD, Kar Saibal, Rinaldi MJ, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med
2011;364:1395-406.
3. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC
guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart
Association task force on clinical practice guidelines. Circulation 2017;70:252-89.
4. Goldstein D, Moskowitz AJ, Gelijns AC, Ailawadi G, Parides MK, et al. Two-year outcomes of surgical treatment of severe ischemic
mitral regurgitation. N Engl J Med 2016;374:344-53.
5. Obadia JF, Messika-Zeitoun D, Leurent G, Iung B, Bonnet G, et al. Percutaneous repair or medical treatment for secondary mitral
regurgitation. N Engl J Med 2018;379:2297-306.
6. Stone GW, Lindenfeld J, Abraham WT, Kar S, Lim DS, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J
Med 2018;379:2307-18.
7. Carabello BA. MitraClip and tertiary mitral regurgitation-mitral regurgitation gets curiouser and curiouser. JAMA Cardiol
2019;4:307-8.
8. Packer M. When cardiovascular trials collide. Eur Heart J 2019;40:501-4.