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Singh et al. Vessel Plus 2018;2:10 Vessel Plus
DOI: 10.20517/2574-1209.2018.18

Case Report Open Access

The first INSPIRIS RESILIA Aortic Valve
TM
replacement (Edwards Lifesciences) in endocarditis

Sanjeet Singh Avtaar Singh , Gwyn Beattie , David Reid , Philip Curry 1
1
1
2
1 Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow G81 4DY, UK.
2 Department of Anaesthesia and Intensive Care, Golden Jubilee National Hospital, Glasgow G81 4DY, UK.
Correspondence to: Dr. Sanjeet Singh Avtaar Singh, Department of Cardiothoracic Surgery, Golden Jubilee National Hospital,
Glasgow G81 4DY, UK. E-mail: sanjeetsingh@nhs.net
TM
How to cite this article: Singh SSA, Beattie G, Reid D, Curry P. The first INSPIRIS RESILIA Aortic Valve replacement (Edwards
Lifesciences) in endocarditis. Vessel Plus 2018;2:10. http://dx.doi.org/10.20517/2574-1209.2018.18
Received: 29 Mar 2018 First Decision: 10 Apr 2018 Revised: 4 May 2018 Accepted: 7 May 2018 Published: 15 May 2018

Science Editor: Cristiano Spadaccio, Mario F. L. Gaudino Copy Editor: Jun-Yao Li Production Editor: Huan-Liang Wu

Abstract
There is an increasing number of patients who have surgery during the active phase of infective endocarditis. Despite
the decreasing in-hospital mortality and increasing early intervention rate, optimal timing for surgery remains a difficult
decision. For patients with mental illnesses, the choice of valve is another factor to consider as non-adherence may lead
to serious adverse events Antipsychotic medications may also alter the metabolism of vitamin K antagonists increasing
the risk of stroke or major haemorrhage. We report a case of a 19-year-old man with a history of Ehlers-Danlos syndrome
and aortic regurgitation, who required management of aortic valve bacterial endocarditis. This is the first report
describing the use of the new RESILIA INSPIRIS valve which has increased durability and does not require anticoagulation.

Keywords: Endocarditis, bio-prosthetic valve, anti-coagulation, Ehler-Danlos syndrome

INTRODUCTION
Infective endocarditis is inflammation of the endocardium, usually of the valves, usually by bacterial
infections. Indications for surgery include symptomatic heart failure, uncontrollable infection, embolic events,
[1]
large vegetations, severe valvular and perivalvular lesions and infections by virulent microorganisms . Risk
factors include structural abnormalities of the cardiac valve which alter flow dynamics (connective tissue
disorders, prosthetic valves) for adherence of bacteria. This allows adhesion of bacteria to the valvular surface
[1]
and propagates as vegetation or systemic emboli .

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
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