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Page 8 of 10                                                     Mueller et al. Vessel Plus 2018;2:13  I  http://dx.doi.org/10.20517/2574-1209.2018.19

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               and P-selectin levels were more important in patients with stable plaques. Further studies combining  FDG-
               PET-CT and MES detection are needed in order to confirm our results.


               DECLARATIONS
               Authors’ contributions
               Contributed to manuscript redaction: Mueller H
               Contributed to patients inclusion: Fisch L, Bonvin C
               Helped to define the the appropriate biomarkers: Lalive P, Pagano S, Vuilleumier N
               Contributed to the PET-CT protocole and to the interpretation of results: Ratib O, Willy JP, Lovblad K
               Contributed to the study design and to manuscript redaction: Sztajzel R

               Availability of data and materials
               All data were collected by our research study nurse and are available.


               Financial support and sponsorship
               The study was granted by the reasearch Center of the University Hospital of Geneve, sustained by the
               National Swiss Foundation.

               Conflicts of interest
               All authors declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               The study was approved by Human Central Ethics commission of University Hospital Geneva and all patients
               gave their written consent.


               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2018.


               REFERENCES
               1.   Golledge J, Greenhalgh RM, Davies AH. The symptomatic carotid plaque. Stroke 2000;31:774-81.
               2.   Spagnoli LG, Mauriello A, Sangiorgi G, Fratoni S, Bonanno E, Schwartz RS, Piepgras DG, Pistolese R, Ippoliti A, Holmes DR Jr.
                   Extracranial thrombotically active carotid plaque as a risk factor for ischemic stroke. JAMA 2004;292:1845-52.
               3.   Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 2012;32:2045-51.
               4.   Jander S, Sitzer M, Schumann R, Schroeter M, Siebler M, Steinmetz H, Stoll G. Inflammation in high-grade carotid stenosis: a possible
                   role for macrophages and T cells in plaque destabilization. Stroke 1998;29:1625-30.
               5.   Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol 2006;47:C13-8.
               6.   Schwartz SM, Galis ZS, Rosenfeld ME, Falk E. Plaque rupture in humans and mice. Arterioscler Thromb Vasc Biol 2007;27:705-13.
               7.   Rudd JH. Imaging atherosclerotic plaque inflammation with [18F]-Fluorodeoxyglucose positron emission tomography. Circulation
                   2002;105:2708-11.
               8.   Marnane M, Merwick A, Sheehan OC, Hannon N, Foran P, Grant T, Dolan E, Moroney J, Murphy S, O’Rourke K, O’Malley K,
                   O’Donohoe M, McDonnell C, Noone I, Barry M, Crowe M, Kavanagh E, O’Connell M, Kelly PJ. Carotid plaque inflammation on
                   18F-fluorodeoxyglucose positron emission tomography predicts early stroke recurrence. Ann Neurol 2012;71:709-18.
               9.   Rudd JH, Myers KS, Bansilal S, Machac J, Woodward M, Fuster V, Farkouh ME, Fayad ZA. Relationships among regional arterial
                   inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positron-emission tomography/computed
                   tomography imaging study. Circ Cardiovasc Imaging 2009;2:107-15.
               10.  Sitzer M, Müller W, Siebler M, Hort W, Kniemeyer HW, Jäncke L, Steinmetz H. Plaque ulceration and lumen thrombus are the main
                   sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke 1995;26:1231-3.
               11.  King A, Markus HS. Doppler embolic signals in cerebrovascular disease and prediction of stroke risk: a systematic review and meta-
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