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Page 8 of 13 Kolba et al. Vessel Plus 2023;7:12 https://dx.doi.org/10.20517/2574-1209.2022.61

Table 3. Preoperative mental illness diagnoses among first-time SAVR and TAVR patients
Percentage of patients with specific mental illness Percentage of first-time SAVR and
Mental illness
diagnoses (total = 4,868; %) TAVR patients (%)
PTSD 0.02 0.20
PTSD-related 0.01 0.10
Depression 0.53 7.03
Anxiety 0.26 3.39
Alcohol-induced mental 0.01 0.12
disorder
Obsessive-compulsive 0.00 0.04
disorder
Bipolar disorder 0.01 0.19
Schizophrenia 0.25 3.32
Mild cognitive impairment 0.01 0.10
Dementia 0.08 1.08

Definitions: PTSD (post-traumatic stress disorder).

[Table 4]. Additional characteristics and risk factors for MEI patients can be found in
[Supplementary Tables 2-13].

Multivariable regression analysis
Post-AVR outcomes
In the AVR population, there were no differences in the POAF rates between MEI patients vs. non-MEI
patients after holding all other risk factors constant (P = 0.5746). Similarly, there were no 30-day
readmission or composite outcome rate differences between MEI patients vs. patients without MEI
(P = 0.1632 and P = 0.8478, respectively) [Table 5].

On multivariable analysis of the AVR population, patients with a MEI diagnosis had no different POAF
rates (AVR, OR = 0.982, 95%CI: 0.920-1.047, P = 0.5746), 30-day readmission rates (AVR, OR = 1.059,
95%CI: 0.977-1.149, P = 0.1632), and 30-day STS composite rates (AVR, OR = 1.010, 95%CI: 0.914-1.116,
P = 0.8478) than patients without MEI.

In the set of full multivariable AVR analysis reports (see Supplementary Tables 2-4 respectively), SAVR vs.
TAVR procedures had high odds ratios reported (POAF OR = 2.16, 95%CI: 2.05-2.28, P < 0.001; READMIT
OR = 2.26, 95%CI: 2.10-2.42, P < 0.001; MM OR 1.63 (1.51-1.76, P < 0.001).

Post r-AVR outcomes
In the r-AVR population, there were no differences in the POAF rates between MEI patients vs. non-MEI
patients (P = 0.4973). Similarly, there were no 30-day readmission or composite rate differences between
MEI patients vs. patients without MEI, after holding all other risk factors constant (P = 0.4860 and
P = 0.2950, respectively) [Table 6].

On multivariable analysis of both r-AVR populations, patients with a MEI diagnosis had no different POAF
rates (r-AVR, OR = 1.335, 95%CI: 0.580-3.072, P = 0.4973), 30-day readmission rates (r-AVR, OR = 0.660,
95%CI: 0.206-2.122, P = 0.4860), and 30-day STS composite rates (r-AVR, OR = 0.591, 95%CI: 0.221-1.581,
P = 0.2950) than patients without a MEI diagnosis.