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Page 4 of 7 Gupta et al. Plast Aesthet Res 2018;5:41 I http://dx.doi.org/10.20517/2347-9264.2018.51

Table 1. Results
Days taken
2
Wound
Serial TBSA % area with for complete Area of unhealed wound in target area (cm ) culture came
Age Sex burn second degree
No. (%) superficial burn healing of Day 0 Day 3 Day 6 Day 10 Day 13 Day 17 positive during
target area treatment
1 26 F 20% 10% 10 1550 1470 500 0 0 0 No
2 35 M 15% 5% 10 900 840 81 0 0 0 No
3 28 M 20% 5% 6 730 630 0 0 0 0 No
4 40 F 16% 10% 13 1740 1650 780 320 0 0 No
5 29 M 20% 15% 10 2500 2480 480 0 0 0 Yes
6 25 F 40% 20% 17 3140 3020 1970 940 230 0 No
7 42 M 35% 15% 10 2430 2200 390 0 0 0 No
8 23 F 30% 20% 10 3280 3130 900 0 0 0 No
9 33 M 30% 15% 13 2250 2170 1300 460 0 0 Yes
10 42 M 15% 10% 13 1600 1600 680 120 0 0 No
11 28 F 35% 20% 13 3070 2900 1910 820 0 0 No
12 26 F 20% 10% 10 1790 1680 580 0 0 0 Yes
13 30 M 40% 25% 17 3970 3870 2340 1090 160 0 Yes
14 35 F 25% 15% 10 2100 2100 690 0 0 0 No
15 26 M 36% 10% 10 1560 1500 380 0 0 0 No
16 19 F 20% 15% 10 2380 2190 690 0 0 0 No
17 28 F 30% 15% 13 2430 2300 1400 480 0 0 No
18 40 F 20% 10% 13 1480 1400 740 185 0 0 Yes
19 24 F 18% 10% 10 1740 1650 560 0 0 0 No
20 32 F 25% 15% 17 2290 2200 1740 890 356 0 No

TBSA: total body surface area

[Figure 2]. Findings were recorded and assessment done when wound healed completely [Figures 3 and 4].
Clinical history and examination were done at the time of each dressing to look for any adverse effect related
to laser therapy. Any pigment changes, itching, erythema or burning of normal skin were considered as
adverse effects related to laser therapy.

RESULTS
A total of twenty patients are included in the study with the mean age 30.55 years (19-42 years). Eight male
and twelve female patients are included. The average time taken for complete healing of areas with second
degree superficial burns was 11.75 (SD 2.86) days. Observations are presented in Table 1. Mean area treated
was 2146 (SD 804) cm which corresponds to 13.5 (SD 5.2) BSA% second degree superficial burns. The patient
2
with the smallest target area was healed on day 6; ten patients were healed on day 10, six patients on day 13,
and three on day 17. Mean sessions of LLLT given for one patient were 3.55 (SD 0.83).

DISCUSSION
[7]
Posten et al. introduced LLLT to improve wound healing. Standard parameters for LLLT are not defined
and various studies used different parameters. The range of parameters used is power output 1-100 mW and
wavelength 300-10,600 nm (red and infrared light). It can be continuous or pulsed. It is given in dose of 0.01-
[7]
2
100 J/cm . The duration of therapy varies between 10 to 3000 s . The commonly used lasers for LLLT are
helium-neon (HeNe), GaAs, indium gallium aluminum phosphorous (InGaAlP), and gallium aluminum
[7]
arsenide (GaAlAs) .
The cytochromes in the mitochondria absorb the laser radiation and convert it into ATP’s which is used for
[8]
stimulation of cell proliferation and synthesis of proteins resulting in photobiological activation of the cell .
Target cells of LLL are myofibroblasts. In animal studies LLLT has been shown to increase myofibroblast