Page 247 - Read Online

agents, and an extreme capacity for evading the host’s REFERENCES
[8]
defenses. An established biofilm structure comprises
microbial cells and an extracellular polymeric substance 1. Kumar P. Exploiting potency of negative pressure in wound dressing using
matrix; it has a defined architecture and it provides an limited access dressing and suction‑assisted dressing. Indian J Plast Surg
optimal environment for the exchange of genetic material 2. 2012;45:302‑15.
Cossart P, Sansonetti PJ. Bacterial invasion: the paradigms of enteroinvasive
between cells. Cells may also communicate via quorum pathogens. Science 2004;304:242‑8.
sensing. The extracellular digestion of biofilms by 3. Waters CM, Bassler BL. Quorum sensing: cell‑to‑cell communication in
[9]
multiple bacteriolytic and proteolytic enzymes is being bacteria. Annu Rev Cell Dev Biol 2005;21:319‑46.
exploited for biofilm control. LAD may be used to 4. Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH. Quenching
[10]
quorum‑sensing‑dependent bacterial infection by an N‑acyl homoserine
mechanically disrupt the biofilm by intermittent negative lactonase. Nature 2001;411:813‑7.
pressure. [1] 5. Miller MB, Bassler BL. Quorum sensing in bacteria. Annu Rev Microbiol
2001;55:165‑99.
Furthermore, wound infection by MDR organisms can be 6. Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL,
effectively treated by applying negative pressure as they Hughson FM. Structural identification of a bacterial quorum‑sensing signal
are resistant to drugs but not to the negative pressure. containing boron. Nature 2002;415:545‑9.
7. Kalia VC. Quorum sensing inhibitors: an overview. Biotechnol Adv
Financial support and sponsorship 8. 2013;31:224‑45.
Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS Suppl
Nil. 2013;136:1‑51.
Conflicts of interest 9. Donlan RM. Biofilms: microbial life on surfaces. Emerg Infect Dis 2002;8:881‑90.
10. Gökçen A, Vilcinskas A, Wiesner J. Biofilm‑degrading enzymes from Lysobacter
There are no conflicts of interest. gummosus. Virulence 2014;5:378‑87.

238 Plast Aesthet Res || Vol 2 || Issue 5 || Sep 15, 2015