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Page 8 of 12            Mitchell et al. Plast Aesthet Res 2023;10:35  https://dx.doi.org/10.20517/2347-9264.2023.14

               Although results are sub-optimal, several studies have shown a reliable return of S2 sensation, which is
               meaningful as this is sufficient enough to provide protective sensation [31,32,45] . Ihara et al. demonstrated a
               more reliable restoration of this S2 level of sensation following ICN nerve transfers compared to
                                          [32]
               supraclavicular sensory transfers .

               Graftable C5
               In the presence of a graftable C5 nerve root, authors who incorporate this technique prefer nerve autograft
               of C5 to the SSN or posterior division of the upper trunk to attempt to restore shoulder stability and
               abduction, as opposed to glenohumeral arthrodesis. The remainder of the reconstructive strategy follows as
               above with a SAN innervated primary FFMT for elbow flexion/wrist extension and a 5th and 6th  ICN
               innervated secondary FFMT for elbow flexion/finger flexion, ICN 3-4 to triceps for elbow extension, and a
                                    [7]
               sensory ICN 3 to LCMN .
               Method 3: contralateral cervical seventh nerve root transfer
               Originally described in 1991 by Gu et al. in Shanghai, China, the CC7 transfer has become another viable
                                            [46]
               option for reconstruction in PBPI . While ICN nerve transfers are considered effective options, they are
               challenging, time-consuming, large dissections with around only 1,300 myelinated axons per donor’s nerve
               compared to the limited dissection and 24,000 axons consistent with a CC7 transfer . Moreover, as most
                                                                                       [47]
               PBPIs occur in high-energy motor vehicle accidents, damage to the chest wall musculature, rib fractures,
               pulmonary contusions, or diaphragm injuries could be contraindications for and preclude the harvest of
               ICN.

               Elbow flexion
               To restore elbow flexion in this technique, the PN is harvested and coapted with the anterior division of the
               upper trunk. This aims to reinnervate the MCN motor branches to the biceps and brachialis. The PN can be
               exposed overlying the anterior scalene. It should be released as distally as possible prior to entering the chest
               cavity. Dissection and isolation of the anterior division of the upper trunk provide the target for this nerve
               coaptation.

               Good/excellent biceps muscle strength was reported by 80% of patients following PN transfer . A recent
                                                                                                [48]
               meta-analysis reported compelling data that PN to MCN transfer is superior to CC7 to MCN transfers in
               regards to reconstituting M3 or M4 elbow flexion . One concern over this transfer is the pulmonary
                                                           [49]
               sequelae of harvesting the PN. However, a series from 2018 demonstrated that this is not a common
                                                                                     [50]
               complication, as no patient developed clinical respiratory problems postoperatively .
               Shoulder stabilization/abduction
               Shoulder abduction may again be accomplished with the transfer of SAN to SSN to reinnervate the
               supraspinatus and infraspinatus muscle bellies. As one of the most common nerve transfers in brachial
               plexus reconstruction, there are several studies that have reported encouraging outcomes with this transfer.
               One study demonstrated good/excellent supraspinatus strength in 79% of patients and good/excellent
               infraspinatus strength in 55% of patients . Along with strength, the literature has shown that with
                                                    [18]
               appropriate coaptation, abduction range of motion recovery can surpass 60 degrees .
                                                                                     [51]
               Elbow extension
               This review has mentioned several nerve transfer techniques to reinnervate triceps motor function. While
               these have shown encouraging results, they are not commonly implemented. Alternatively, it has been an
               acceptable option to allow elbow extension to be controlled by gravity alone. Coordinated elbow positioning
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