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Topic: Biomaterials for Plastic and Aesthetic Surgery

Advances in the research of autologous

fibroblast injections for aging skin

Meng-Yao Tang, Rong Jin, Ying Zhang, Yao-Ming Shi, Bao-Shan Sun, Lu Zhang,
Yu-Guang Zhang
Department of Plastic and Reconstructive, Shanghai Ninth People’s Hospital affilicated to Medical School of Shanghai Jiao Tong
University, Shanghai 200011, China.
Address for correspondence: Prof. Yu-Guang Zhang, Department of Plastic and Reconstructive, Shanghai Ninth People’s Hospital affilicated to
Medical School of Shanghai Jiao Tong University, No. 639 Zhi Zao Ju Road, Shanghai 200011, China. E-mail: zhangyg18@126.com

ABSTRACT
With the development of autologous stem cells transplantation, the application of autologous fibroblast
graft has been an important therapy in defect repair. In the past decade, amounts of studies have
reported favorable treatment effect and safety about the therapy. The material has the ability to produce
human collagen in vivo. This article details recent scientific work of the cases, effect, injection technique,
complications and safety of autologous fibroblast injection treatment.

Key words:
Autologous fibroblast; injection; aging skin

INTRODUCTION a common kind of dermal filler, that is to say, it is not volume
filler. As a result, it’s very important to notify patients that
Wrinkles can be corrected by using various treatment the therapy does not take effect in a short time. Fibroblasts
methods like lasers, soft tissue fillers, Botox for dynamic show mitigating improvement after about 3 serial treatment
wrinkles, and so on. The most common therapy is dermal processes and living cells keep vigorous growth that may
[9]
fillers like hyaluronic acid. However, dermal fillers are lead to greater persistence than other fillers. Autologous
typically degradable or semipermanent, and liable to allergic cultured fibroblasts have been used effectively for dermal
[10]
reaction or other side reactions like skin necrosis, visual and subcutaneous deficiencies since 1995. Autologous
impairment. Autologous materials have been used for more fibroblast transplantation first received approval from the
[1]
than a century for soft tissue augmentation. Autologous fat US Food and Drug Administration in June 2011 to improve
has always been the first choice of autologous graft. However, moderate or severe nasolabial fold wrinkles.
the high rate of graft resorption and unpredictable degree
of volume loss in some degree reduced the enthusiasm for CASES AND TREATMENT OUTCOME
the use of adipose grafts in soft tissue augmentation. With
[2]
the development of autologous stem cells transplantation, In the past decade, amounts of studies have reported
the application of autologous fibroblast graft has been an favorable treatment effect and safety about the therapy. [11-13]
important therapy in defect repair. [3-7] Fibroblasts are the Clinical researches for autologous fibroblast therapy have
main functional cells in dermis and autologous fibroblasts been carried on since 2001. Cultured autologous fibroblasts
injection may be more beneficial than other therapies in
facial rejuvenation. Autologous fibroblasts injection is not This is an open access article distributed under the terms of the Creative Commons
[8]
Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix,
tweak and build upon the work non-commercially, as long as the author is credited
and the new creations are licensed under the identical terms.
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Website:
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How to cite this article: Tang MY, Jin R, Zhang Y, Shi YM, Sun
BS, Zhang L, Zhang YG. Advances in the research of autologous
DOI: fibroblast injections for aging skin. Plast Aesthet Res 2016;3:83-5.
10.20517/2347-9264.2015.118
Received: 02-11-2015; Accepted: 10-12-2015
© 2016 Plastic and Aesthetic Research | Published by OAE Publishing Inc. 83