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Grewal et al. Plast Aesthet Res 2021;8:37  https://dx.doi.org/10.20517/2347-9264.2021.43  Page 3 of 14

               an intraoperative workflow with an emphasis on efficiency and patient safety [Figure 1].


               General considerations: patient population, team assembly, & financial plan
               Patient population
               Patients with benign jaw disease localized to the maxilla or mandible who are motivated to have immediate
               dental tooth replacement have the most to be gained from this procedure. The ideal JIAD candidate patient
               is one with benign disease such as an odontogenic keratocyst (OKC), ameloblastoma, odontogenic
               myxoma, or medication-related osteonecrosis of the jaw (MRONJ), a stable existing occlusion, and high
               post-operative expectations. Additionally, good oral hygiene and intact dentition is a must; this procedure is
               less successful in recreating dentition or occlusion already lost to disease. Patients with oncologic disease
               processes that require post-operative radiation are less favorable as radiation can damage bone
               mineralization, reducing osteointegration of the implants. However, several centers have expanded the
                                                                                    [4]
               application to patients with malignancies, without increased rate of complications .

               Once a patient has been selected, a multidisciplinary team with clearly defined roles is established. The team
               consists of an ablative surgeon, a microvascular trained reconstructive surgeon [either Otolaryngology -
               Head and Neck Surgery, Oral and Maxillofacial Surgeon (OMS), or Plastic Surgeon], and an appropriately
               trained prosthodontist, usually a maxillofacial prosthodontist. The surgeons are responsible for ablation of
               the disease, harvesting and inset of a vascularized free flap, and closure of the head and neck incisions. An
               OMS assists with the ablation and inset, and completes the implant placement. Finally, a prosthodontist
               designs the prosthesis, loads the prosthesis to the DIs, and oversees postoperative modifications to ensure
               proper occlusion and function of the maxillary and mandibular teeth. Regarding the post-operative oral
               rehabilitation and functional occlusion, a dedicated prosthodontist is critical to procedural success.
               Practitioners must be aware of the length, complexity and multidisciplinary nature of the operation; they
               should be willing to undertake the significant risks of a time intensive surgical procedure and should be
               experts in their respective fields.


               This procedure can be a significant financial burden to the patient. Often times, as medical insurance does
               not cover dental rehabilitation, the patient will incur most of the dental related expenses which may include
               the placement of DIs and almost always includes the cost of the provisional and definitive prostheses. The
               cost of the implants themselves can be bundled with hospital materials management. However, the costs of
               the provisional acrylic prosthesis, all related components, and the definitive prosthesis of zirconia or
               porcelain can still approach tens of thousands of dollars. While fees may vary per geographic region, these
               fees are comparable to traditional prosthetic work that requires precious materials and high laboratory fees.
               The patient should be counselled as to a feasible financial plan for affording the operation and dental
               treatment options.


               Preoperative preparation
               Ablation and reconstruction
               Before proceeding with the operation, the team will need to evaluate the location and extent of the patient’s
               pathology as well as the condition of their existing dentition. The patient will also need a lower extremity
               CT angiogram to evaluate patency of the peroneal vessels and adequate three-vessel run-off to determine
               the best candidate leg for graft harvest.

               Prosthodontist consult
               Data collection
               The prosthodontist will obtain intraoral and extraoral preliminary photos for documentation and
               evaluation purposes. Either an intraoral scan or a conventional impression is taken to produce a digital or
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