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Abadías-Granado et al. Plast Aesthet Res 2021;8:27 Plastic and
DOI: 10.20517/2347-9264.2020.199
Aesthetic Research

Review Open Access

The microbiome and aging

1
2
Isabel Abadías-Granado , Javier Sánchez-Bernal , Yolanda Gilaberte 1
1
Department of Dermatology, Miguel Servet University Hospital, IIS Aragón, Zaragoza 50009, Spain.
2
Department of Dermatology, San Jorge General Hospital, Huesca 22004, Spain.
Correspondence to: Dr. Isabel Abadías-Granado, Department of Dermatology, Miguel Servet University Hospital, Paseo Isabel la
Católica, 1-3, Zaragoza 50009, Spain. E-mail: isabel.abadiasg@gmail.com
How to cite this article: Abadías-Granado I, Sánchez-Bernal J, Gilaberte Y. The microbiome and aging. Plast Aesthet Res
2021;8:27. https://dx.doi.org/10.20517/2347-9264.2020.199

Received: 30 Oct 2020 First Decision: 19 Mar 2021 Revised: 1 Apr 2021 Accepted: 25 Apr 2021 Published: 20 May 2021

Academic Editors: Salvador Gonzalez, Raúl González-García Copy Editor: Xi-Jun Chen Production Editor: Xi-Jun Chen

Abstract
The microbiota changes as the host ages, but also the relationship between host and bacteria impacts host aging
and life expectancy. Differences in the composition of certain bacterial species in the human gut and skin
microbiome have been identified between the elderly and the young. In this sense, it has been suggested that the
manipulation of the microbiota of older adults would be an innovative strategy in the prevention and treatment of
age-related comorbidities.

Keywords: Microbiome, aging, skin aging, skin cancer, probiotics

INTRODUCTION
Humans are practically sterile during gestation, but, as early as birth, the whole body surface, including the
oral cavity, gut, and skin, are colonized by an enormous variety of microbes, fungal, archaeal, bacterial, and
viral . There is a very complex relationship between the resident microbial communities and the human
[1]
cells. These species and their metabolic products play an important role in a wide range of biological
[2]
functions . In normal life, these microbes are necessary for many functions, such as developing and
maintaining our immune system or digesting food. However, the dysfunction of the human microbiota is
[1,3]
considering a relevant factor in many diseases .

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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