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Philips et al. Plast Aesthet Res 2022;9:4 Plastic and
DOI: 10.20517/2347-9264.2021.83
Aesthetic Research

Review Open Access

Anti-aging and anti-carcinogenic effects of 1α, 25-
dihyroxyvitamin D on skin
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1
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Neena Philips , Mikel Portillo-Esnaola , Philips Samuel , Maria Gallego-Rentero , Tom Keller , Jan
Franco 1
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Department of Biological Sciences, Fairleigh Dickinson University, Teaneck, NJ 07601, USA.
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Department of Biology, Autónoma University of Madrid (UAM), Madrid 28049, Spain.
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Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid 28049, Spain.
Correspondence to: Dr. Neena Philips, Department of Biological Sciences, Fairleigh Dickinson University, H-DH4-03, Teaneck,
NJ 07666, USA. E-mail: nphilips@fdu.edu
How to cite this article: Philips N, Portillo-Esnaola M, Samuel P, Gallego-Rentero M, Keller T, Franco J. Anti-aging and anti-
carcinogenic effects of 1α, 25-dihyroxyvitamin D on skin. Plast Aesthet Res 2022;9:4. https://dx.doi.org/10.20517/2347-
3
9264.2021.83
Received: 20 Jul 2021 First Decision: 26 Nov 2021 Revised: 13 Dec 2021 Accepted: 17 Dec 2021 Published: 14 Jan 2022
Academic Editor: Salvador Gonzalez Copy Editor: Xi-Jun Chen Production Editor: Xi-Jun Chen

Abstract
Photoaging and carcinogenesis are facilitated by oxidative stress, inflammation, angiogenesis, and extracellular
matrix (ECM) remodeling. Oxidative effects include DNA damage, membrane oxidation, lipid peroxidation, and
alterations in the expression of p53 and antioxidant enzymes. The inflammatory and angiogenesis mediators
include interleukin-1, tumor necrosis factor-α, interleukin-8, transforming growth factor-β, and vascular endothelial
growth factor. ECM remodeling includes alterations in the expression and organization of collagen, elastin, matrix
metalloproteinases, and elastase. 1α, 25-dihydroxy-vitamin D has antioxidant, anti-inflammatory, and ECM
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regulatory properties, and can counteract the processes that facilitate photoaging and carcinogenesis. This review
provides an overview of the beneficial effects of vitamin D supplementation at a molecular level, followed by a brief
discussion regarding its use as a supplement.
Keywords: Ultraviolet radiation, superoxide dismutase, p53, interleukins, tumor necrosis factor- , transforming
growth factor- , vascular endothelial growth factor, collagen, elastin, matrix metalloproteinases

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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