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more than 12 weeks. Solid evidence on the effect of delays within this interval is still lacking and is beyond
the scope of this review.

Postoperative complications - especially major complications resulting in re-operation - were found to be
associated with delay in the initiation of adjuvant therapy. Based on this, it is evident to reason that the
development of postoperative complications rather than the type of procedure performed determines the
initiation of adjuvant therapy. This underlines the importance of taking right measures to minimize the risk
of postoperative complications. These measures include careful patient selection, a multidisciplinary
treatment approach at a highly specialized facility, and possibly the implementation of up-to-date
intraoperative modalities such as ICG-angiography. Further research in this field, preferably large
multicenter studies, would be appreciated.

DECLARATIONS
Authors’ contributions
Contributed to the writing and revision of the manuscript: Dengsoe IB, Sabitovic A, Damsgaard TE

Availability of data and materials
No template data collection forms, data extracted from included studies, data used for analyses, analytic
code or any other materials used in this review are publicly available.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2024.

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