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Page 122        Constantinides et al. Neuroimmunol Neuroinflammation 2020;7:120-31  I  http://dx.doi.org/10.20517/2347-8659.2019.22

               Table 1. Overview of the studies with data on classical CSF biomarkers in cohorts with Parkinsonism
                                         Aβ 42            τ Τ            τ P-181        Comparison group
                Studies in PSP
                Holmberg et al. [10]     ↔                                            Ctrl, MSA, PD
                Verbeek et al. [11]      ↔                                            Ctrl, MSA, PD
                                                           b
                Aerts et al. [12]        ↔ a              ↓  ↑ c          ↔ a         a. CBD, PD, ctrl
                                                                                      b. CBD
                                                                                      c. PD
                                           a
                Hall et al. [13]         ↔  ↑ b           ↔ c             ↓ d         a. MSA, CBD, PD, PDD, ctrl
                                                                                      b. DLB
                                                                                      c. ctrl, CBD, MSA
                                                                                      d. ctrl
                Schoonenboom et al. [14]  ↔               ↔               ↔           DLB, CBD, ctrl
                Magdalinou et al. [15]   ↔                ↔               ↔           CBD, MSA, PD, ctrl
                Constantinides et al. [16]  ↔             ↔               ↔           MSA, PD, CBD, ctrl
                Noguchi et al. [17]      ↓ a              ↔ b             ↔ b         a. ctrl
                                                                                      b. ctrl, CBD
                Wagshal et al. [18]      ↓                ↓               ↔           ctrl
                Schirinzi et al. [19]    ↓                ↓               ↓           ctrl
                Süssmuth et al. [20]     ↔                ↔               ↔           MSA, PD
                Studies in CBD
                Aerts et al. [12]        ↔ a              ↑ a             ↑ b         a. ctrl, PSP, PD
                                                                          ↔ c         b. PD
                                                                                      c. ctrl, PSP
                                                           b
                Constantinides et al. [16]  ↓ a           ↑  ↔ c          ↔ d         a. PD
                                                                                      b. ctrl
                                                                                      c. PSP, MSA, PD
                                                                                      d. PSP, MSA, PD, ctrl
                Mitani et al. [21]                        ↑                           ctrl
                Urakami et al. [22]                       ↑                           ctrl, PSP
                Urakami et al. [23]                       ↑                           ctrl, PSP
                Hall et al. [13]         ↔  ↑ b           ↑  ↔ d          ↔  ↑ f      a. MSA, PSP, PD, PDD, ctrl
                                                                           e
                                           a
                                                           c
                                                                                      b. DLB
                                                                                      c. PD
                                                                                      d. PSP
                                                                                      e. PSP, PD, ctrl
                                                                                      f. MSA
                Schoonenboom et al. [14]  ↓               ↔               ↔           ctrl
                Magdalinou et al. [15]   ↔                ↔               ↔           MSA, PSP, PD, ctrl
                                           a
                Noguchi et al. [17]      ↔  ↓ b           ↔ c             ↔ c         a. PSP
                                                                                      b. ctrl
                                                                                      c. ctrl, PSP
                Studies in MSA
                Holmberg et al. [10]     ↓                                            PD, PSP, ctrl
                Shi et al. [26]          ↓  ↔ b           ↔ c             ↔ c         a. ctrl
                                          a
                                                                                      b. PD
                                                                                      c. ctrl,PD
                Verbeek et al. [11]      ↔                                            Ctrl, PD
                                           a
                Hall et al. [13]         ↔  ↑ b           ↑ c             ↓ d         a. MSA, CBD, PD, PDD, ctrl
                                                                                      b. DLB
                                                                                      c. PD, PDD
                                                                                      d. PD, ctrl
                Magdalinou et al. [15]   ↔                ↔               ↔           CBD, PSP, PD, ctrl
                Constantinides et al. [16]  ↔             ↔               ↔           PSP, CBD, PD, ctrl
                Süssmuth et al. [20]     ↔ a              ↑ b             ↔ c         a. PD, PSP
                                                                                      b. ctrl, PD
                                                                                      c. PSP, PD, ctrl
                Mollenhauer et al. [27]  ↔                ↔                           PSP, PD
                Abdo et al. [28]                          ↑                           ctrl
                Herbert et al. [29]                       ↑                           Ctrl, PD
                Abdo et al. [30]                          ↑                           PD
                Herbert et al. [31]                       ↑                           PD
                Studies in DLB
                                          a
                Schoonenboom et al. [14]  ↓  ↑ b          ↓  ↑ a          ↓  ↑ a      a. ctrl
                                                                          b
                                                           b
                                                                                      b. AD
   49   50   51   52   53   54   55   56   57   58   59