Page 52 - Read Online

Constantinides et al. Neuroimmunol Neuroinflammation 2020;7:120-31 Neuroimmunology
DOI: 10.20517/2347-8659.2019.22 and Neuroinflammation

Review Open Access

Cerebrospinal fluid amyloid beta and tau proteins in
atypical Parkinsonism: a review

Vasilios C. Constantinides , George P. Paraskevas , Fotini Boufidou , Mara Bourbouli , Panagiotis G.
2
1
1
1
Paraskevas , Leonidas Stefanis , Elisabeth Kapaki 1
3
1
1 1st Department of Neurology, National and Kapodistrian University of Athens, Athens, P.C. 11528, Greece.
2 Department of Neurology, University of Crete, Heraklion 70013, Greece.
3 Department of Nursing, Technological Educational Institute of Crete, Heraklion 71500, Greece.
Correspondence to: Dr. Vasilios C. Constantinides, 1st Department of Neurology, National and Kapodistrian University of
Athens, School of Medicine, Eginition Hospital,72 Vas. Sofias Ave, Athens 11528, Greece.
E-mail: vconstan@med.uoa.gr; vassilis.kon@hotmail.com
How to cite this article: Constantinides VC, Paraskevas GP, Boufidou F, Bourbouli M, Paraskevas PG, Stefanis L, Kapaki E.
Cerebrospinal fluid amyloid beta and tau proteins in atypical Parkinsonism: a review. Neuroimmunol Neuroinflammation
2020;7:120-31. http://dx.doi.org/10.20517/2347-8659.2019.22

Received: 17 Dec 2019 First Decision: 2 Mar 2020 Revised: 25 Mar 2020 Accepted: 7 Apr 2020 Available online: 16 May 2020

Science Editor: Athanassios P. Kyritsis Copy Editor: Jing-Wen Zhang Production Editor: Jing Yu

Abstract
Progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy and dementia with Lewy
bodies are the most common causes of atypical Parkinsonism and enter the differential diagnosis of Parkinson’s
disease. multiple system atrophy, dementia with Lewy bodies and Parkinson’s disease are synucleinopathies,
whereas progressive supranuclear palsy and corticobasal degeneration are tauopathies. Multiple cerebrospinal
fluid markers have been applied on cohorts of patients with Parkinsonism, with the aim to develop biomarkers for
these disorders. Total tau (τ Τ ), phosphorylated tau at threonine 181 (τ P -181) and amyloid-beta with 42 amino acids
(Aβ 42 ) are considered classical biomarkers for Alzheimer’s disease. The aim of the present study is to review the
literature regarding these classical cerebrospinal fluid biomarkers in cohorts with Parkinsonism, as well as present
data on novel approaches regarding analysis of these proteins.

Keywords: Biomarkers, cerebrospinal fluid, progressive supranuclear palsy, corticobasal degeneration, multiple
system atrophy, dementia with Lewy bodies, tau protein, phosphorylated tau protein, amyloid beta

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

www.nnjournal.net