Page 132 - Read Online

Souza et al. Neuroimmunol Neuroinflammation 2019;6:12 I http://dx.doi.org/10.20517/2347-8659.2019.04 Page 11 of 13

Performed data acquisition, as well as provided administrative, technical, and material support: Souza RN,
Lopes JMA, Monteiro LRN, Barbosa RAQ, Hollmann G, Allodi S, Reis LC, Medeiros MA

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by FAPERJ (Research support foundation in the state of Rio de Janeiro) (grand
number: 111.616/2010).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
All procedures were approved by the Ethics Committee on Research of the Federal Rural University of Rio
de Janeiro (23083.005880/2013).

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

REFERENCES
1. Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol 2008;85:355-75.
2. Lin JG, Chen CJ, Yang HB, Chen YH, Hung SY. Electroacupuncture promotes recovery of motor function and reduces dopaminergic
neuron degeneration in rodent models of Parkinson’s disease. Int J Mol Sci 2017;18:E1846.
3. Yang EJ, Jiang JH, Lee SM, Yang SC, Hwang HS, et al. Bee venom attenuates neuroinflammatory events and extends survival in
amyotrophic lateral sclerosis models. J Neuroinflammation 2010;7:69.
4. Choi DC, Lee JY, Moon YJ, Kim SW, Oh TH, et al. Acupuncture-mediated inhibition of inflammation facilitates significant functional
recovery after spinal cord injury. Neurobiol Dis 2010;39:272-82.
5. Wei Z, Zhao W, Schachner M. Electroacupuncture restores locomotor functions after mouse spinal cord injury in correlation with
reduction of PTEN and p53 expression. Front Mol Neurosci 2018;11:411.
6. Park JY, Namgung U. Electroacupuncture therapy in inflammation regulation: current perspectives. J Inflamm Res 2018;11:227-37.
7. Zhao J, Wang L, Li Y. Electroacupuncture alleviates the inflammatory response via effects on M1 and M2 macrophages after spinal
cord injury. Acupunct Med 2017;35:224-30.
8. Kang SY, Roh DH, Choi JW, Ryu Y, Lee JH. Repetitive treatment with diluted bee venom attenuates the induction of below-level
neuropathic pain behaviors in a rat spinal cord injury model. Toxins 2015;7:2571-85.
9. Son DJ, Lee JW, Lee YH, Song HS, Lee CK, et al. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of
bee venom and its constituent compounds. Pharmacol Ther 2007;115:246-70.
10. Cherniack EP, Govorushko S. To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans. Toxicon
2018;154:74-8.
11. Zhang S, Liu Y, Ye Y, Wang XR, Lin LT, et al. Bee venom therapy: Potential mechanisms and therapeutic applications. Toxicon
2018;148:64-73.
12. Kim HW, Kwon YB, Han HJ, Yang IS, Beitz AJ, et al. Antinociceptive mechanisms associated with diluted bee venom acupuncture
(apipuncture) in the rat formalin test: involvement of descending adrenergic and serotonergic pathways. Pharmacol Res 2005;51:183-8.
13. Park HJ, Lee SH, Son DJ, Oh KW, Kim KH, et al. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation
by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis Rheum 2004;50:3504-15.
14. Lee JD, Park HJ, Chae Y, Lim S. An overview of bee venom acupuncture in the treatment of arthritis. Evid Based Complement
Alternat Med 2005;2:79-84.
15. Seo BK, Lee JH, Sung WS, Song EM, Jo DJ. Bee venom acupuncture for the treatment of chronic low back pain: study protocol for a
randomized, double-blinded, sham-controlled trial. Trials 2013;14:16.
16. Ostrovsky DA, Ehrlich A. Bee venom acupuncture in addition to anti-parkinsonian medications may improve activities of daily living
and motor symptoms more than medication alone in idiopathic parkinson’s disease. Explore (NY) 2019;15:71-3.