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Orsucci et al. Neuroimmunol Neuroinflammation 2018;5:7 I http://dx.doi.org/10.20517/2347-8659.2017.67 Page 3 of 5

A Inteross dors I (Spont) G Gastroc caput med (Spont)

0.1 mV 0.1 mV
10 ms 10 ms
B Inteross dors I (Spont) H Gastroc caput med (Spont)

0.1 mV 0.1 mV
10 ms 10 ms
C Tibialis anterior (Spont)
I Gastroc caput med (Spont)

0.1 mV
10 ms 0.1 mV
D Tibialis anterior (Spont) 10 ms
J Gastroc caput med (IP)

0.1 mV 2 mV
10 ms 20 ms
E Tibialis anterior (Spont) K Tibialis anterior (IP)

0.1 mV 2 mV
10 ms 20 ms
L Tibialis anterior (IP)
F Tibialis anterior (Spont)

0.1 mV 2 mV
10 ms 20 ms
Figure 1. Continuous spontaneous activity in all the examined muscle districts. Electromyography showing abnormal repetitive spontaneous
activity of the muscle fibers (doublet, triplet, or multiple single-unit discharges with high, irregular intraburst frequency) in all the muscle
groups (reported in the figure). (A-E) Right side; (F-G) left side. Spont: spontaneous activity