Page 37 - Read Online
P. 37

Llamoza-Torres et al. Metab Target Organ Damage 2024;4:40  https://dx.doi.org/10.20517/mtod.2024.64  Page 17 of 18

                    risk assessment. Liver Int 2024;Online ahead of print.  DOI  PubMed
               108.      Burke L, Hinkson A, Haghnejad V, Jones R, Parker R, Rowe IA. Hepatocellular carcinoma risk scores for non-viral liver disease: a
                    systematic review and meta-analysis. JHEP Reports 2024;Online ahead of print.  DOI
               109.      Kalligeros M, Henry L, Younossi ZM. Metabolic dysfunction-associated steatotic liver disease and its link to cancer. Metabolism
                    2024;160:156004.  DOI  PubMed
               110.      Thomas JA, Kendall BJ, Dalais C, Macdonald GA, Thrift AP. Hepatocellular and extrahepatic cancers in non-alcoholic fatty liver
                    disease: a systematic review and meta-analysis. Eur J Cancer 2022;173:250-62.  DOI  PubMed
               111.      Day CP, James OF. Steatohepatitis: a tale of two “hits”? Gastroenterology 1998;114:842-5.  DOI  PubMed
               112.      Kazankov K, Jørgensen SMD, Thomsen KL, et al. The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic
                    steatohepatitis. Nat Rev Gastroenterol Hepatol 2019;16:145-59.  DOI  PubMed
                                                                                             +
               113.      Hendrikx T, Porsch F, Kiss MG, et al. Soluble TREM2 levels reflect the recruitment and expansion of TREM2  macrophages that
                    localize to fibrotic areas and limit NASH. J Hepatol 2022;77:1373-85.  DOI  PubMed
               114.      Zucman-Rossi  J,  Villanueva  A,  Nault  JC,  Llovet  JM.  Genetic  landscape  and  biomarkers  of  hepatocellular  carcinoma.
                    Gastroenterology 2015;149:1226-39.e4.  DOI  PubMed
               115.      Sia D, Jiao Y, Martinez-Quetglas I, et al. Identification of an immune-specific class of hepatocellular carcinoma, based on molecular
                    features. Gastroenterology 2017;153:812-26.  DOI  PubMed
               116.      Jaitin DA, Adlung L, Thaiss CA, et al. Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner.
                    Cell 2019;178:686-98.e14.  DOI  PubMed  PMC
               117.      Fredrickson G, Florczak K, Barrow F, et al. TREM2 macrophages mediate the beneficial effects of bariatric surgery against MASH.
                    Hepatology 2024;Online ahead of print.  DOI  PubMed
               118.      Ding T, Xu J, Wang F, et al. High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary
                    hepatocellular carcinoma after resection. Hum Pathol 2009;40:381-9.  DOI  PubMed
               119.      Kuang DM, Zhao Q, Peng C, et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege
                    and disease progression through PD-L1. J Exp Med 2009;206:1327-37.  DOI  PubMed  PMC
               120.      Wang Q, Lin Y, Yu W, Chen X, He Q, Ye Z. The core role of macrophages in hepatocellular carcinoma: the definition of molecular
                    subtypes and the prognostic risk system. Front Pharmacol 2023;14:1228052.  DOI  PubMed  PMC
               121.      Zhao S, Jang C, Liu J, et al. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 2020;579:586-91.  DOI
                    PubMed  PMC
               122.      Hu C, Xu B, Wang X, et al. Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC.
                    Hepatology 2023;77:48-64.  DOI  PubMed  PMC
               123.      Qin S, Chen M, Cheng AL, et al; IMbrave050 investigators. Atezolizumab plus bevacizumab versus active surveillance in patients
                    with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial.
                    Lancet 2023;402:1835-47.  DOI  PubMed
               124.      Lencioni  R,  Kudo  M,  Erinjeri  J,  et  al.  EMERALD-1:  a  phase  3,  randomized,  placebo-controlled  study  of  transarterial
                    chemoembolization combined with durvalumab with or without bevacizumab in participants with unresectable hepatocellular
                    carcinoma eligible for embolization. JCO 2024;42:LBA432.  DOI
               125.      Llovet J, Finn R, Ren Z, et al. LBA3 transarterial chemoembolization (TACE) with or without lenvatinib (len) + pembrolizumab
                    (pembro) for intermediate-stage hepatocellular carcinoma (HCC): phase III LEAP-012 study. Annals of Oncology 2024;35:S1229.
                    DOI
               126.      Llovet JM, Ricci S, Mazzaferro V, et al; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl
                    J Med 2008;359:378-90.  DOI  PubMed
               127.      Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced
                    hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10:25-34.  DOI  PubMed
               128.      Kudo M, Finn RS, Qin S, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular
                    carcinoma: a randomised phase 3 non-inferiority trial. Lancet 2018;391:1163-73.  DOI  PubMed
               129.      Finn RS, Qin S, Ikeda M, et al; IMbrave150 Investigators. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma.
                    N Engl J Med 2020;382:1894-905.  DOI  PubMed
               130.      Ren Z, Xu J, Bai Y, et al; ORIENT-32 study group. Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in
                    unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2-3 study. Lancet Oncol 2021;22:977-90.  DOI
                    PubMed
               131.      Kelley RK, Rimassa L, Cheng AL, et al. Cabozantinib plus atezolizumab versus sorafenib for advanced hepatocellular carcinoma
                    (COSMIC-312): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol 2022;23:995-1008.  DOI  PubMed
               132.      Abou-Alfa GK, Lau G, Kudo M, et al. Tremelimumab plus durvalumab in unresectable hepatocellular carcinoma. NEJM Evid
                    2022;1:EVIDoa2100070.  DOI  PubMed
               133.      Qin S, Kudo M, Meyer T, et al. Tislelizumab vs sorafenib as first-line treatment for unresectable hepatocellular carcinoma: a phase 3
                    randomized clinical trial. JAMA Oncol 2023;9:1651-9.  DOI  PubMed  PMC
               134.      Qin S, Chan SL, Gu S, et al; CARES-310 Study Group. Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for
                    unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study. Lancet 2023;402:1133-
                    46.  DOI  PubMed
   32   33   34   35   36   37   38   39   40   41   42