Page 13 - Read Online

Ding et al. Microbiome Res Rep 2024;3:16 https://dx.doi.org/10.20517/mrr.2023.64 Page 7 of 16

Figure 3. Effects of B. longum subsp. infantis on the expression of the related genes in the JAK/STAT pathway in the colon of female (A-
F) and male mice (G-L). (A) JAK1; (B) JAK2; (C) STAT1; (D) STAT6; (E) T-bet; (F) GATA3; (G) JAK1; (H) JAK2; (I) STAT1; (J) STAT6;
*
**
(K) T-bet; (L) GATA3. P < 0.05, P < 0.01, compared to corresponding gender control group. The mean ± SEM (n = 8 per group) was
used to represent the data. SEM: Error of the mean.
GATA3 in the colon of female mice [Figure 3F]. For male groups, B. longum subsp. infantis I5TI and
B6MNI increased the JAK1 mRNA relative expression (P < 0.05, Figure 3G). No significant differences were
found in the relative expression of JAK2 and STAT1 in the colon of male mice [Figure 3H and I], while