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Misera et al. Microbiome Res Rep 2024;3:48 https://dx.doi.org/10.20517/mrr.2023.81 Page 13 of 19

Immunohistochemistry: increased intervention
5-HT in DRN
CUMS Male C57BL/6J A. muciniphila Behavioral tests (OFT, FST, TST, Serum, gut tissue, Behavioral tests: increased distance A. muciniphila alleviates The study was only Guo
mice, 6-8 weeks, (ATTC BAA-835) SPT), ELISA, qRT-PCR, 16S rRNA brain (PFC) tissue in OFT, decreased immobility in depressive-like behaviors by conducted on male et al.,
9 [97]
n = 45 (2.5 × 10 CFU/200 gene sequencing, histology, FST and TST, increased sucrose increasing 5-HT levels in the mice; the effects on 2024
µL), daily for immunohistochemistry preference in SPT gut and brain, modulating gut female mice were
5 weeks ELISA: increased 5-HT in gut and microbiota, and improving unknown
PFC, decreased corticosterone colonic structure Mechanisms of
qRT-PCR: increased Tph1 in gut, MGBA interaction
increased BDNF in brain not fully elucidated
16S rRNA gene sequencing: altered
gut microbiota composition
Histology: improved colonic
structure
Immunohistochemistry: increased
MUC2 expression

CAE Male C57BL/6J A. muciniphila (2.5 × Behavioral tests (OFT, FST, TST, Serum, gut tissue, Behavioral tests: increased distance A. muciniphila alleviates The study was only Guo
9
mice, 8 weeks, 10 CFU/200 µL), SPT), ELISA, qRT-PCR, 16S rRNA brain (PFC) tissue in OFT, decreased immobility in depressive-like behaviors by conducted on male et al.,
[97]
n = 48 daily for 5 weeks gene sequencing, histology, FST and TST, increased sucrose increasing 5-HT levels in the mice; the effects on 2024
immunohistochemistry preference in SPT gut and brain, modulating gut female mice are
ELISA: increased 5-HT in gut and microbiota, and improving unknown
PFC, decreased corticosterone colonic structure Mechanisms of
qRT-PCR: increased Tph1 in gut, MGBA interaction
increased BDNF in brain not fully elucidated
16S rRNA gene sequencing: altered
gut microbiota composition
Histology: improved colonic
structure
Immunohistochemistry: increased
MUC2 expression

CUMS Male C57BL/6 Amuc_1100Δ80 Behavioral tests (LDB, OFT, EPM, Serum, colon Behavioral tests: increased entries Amuc_1100Δ80 alleviates The study was only Cheng
mice, 5-6 weeks, (80 μg/day) for FST, TST), ELISA, qRT-PCR, 16S tissue, and time in light chamber (LDB), anxiety and depression-like conducted on male et al.,
[ 98]
n = 6 per group 3 weeks rRNA gene sequencing, hippocampus increased distance traveled (OFT), behaviors, modulates gut mice; effects on 2022
immunohistochemistry tissue, fecal increased open arm entries (EPM), microbiota, increases 5-HT females are
samples decreased immobility (FST, TST) levels, and enhances the 5- unknown
ELISA: increased 5-HT in serum and HTR1A-CREB-BDNF signaling Short duration of
hippocampus, decreased pathway intervention
corticosterone Mechanisms of
qRT-PCR: increased Tph1 in colon, MGBA interaction
increased BDNF, CREB1, 5-HTR1A not fully elucidated
in hippocampus
16S rRNA gene sequencing:
improved gut microbiota diversity
and composition
Immunohistochemistry: increased
MUC2 expression

Antibiotic- Male C57BL/6 A. muciniphila (1.5 × Behavioral tests (LDB, OFT, EPM, Serum, Behavioral tests: increased entries A. muciniphila and Amuc_1100 The study was only Sun
9
induced mice, 6 weeks, 10 CFU/200 µL), TST, FST), ELISA, qRT-PCR, 16S hippocampus, and and time in light chamber (LDB), alleviate antibiotic-induced conducted on male et al.,
anxiety and 20 ± 2 g, n = 32 Amuc_1100 (100 rRNA gene sequencing, fecal samples increased distance traveled (OFT), anxiety and depression by mice; the effects on 2023 [8]