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Misera et al. Microbiome Res Rep 2024;3:48 Microbiome Research
DOI: 10.20517/mrr.2023.81
Reports

Review Open Access

Possible application of Akkermansia muciniphila in
stress management

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1
Agata Misera , Wojciech Marlicz 2 , Albert Podkówka , Igor Łoniewski 3 , Karolina Skonieczna-Żydecka 3
1
Department of Psychiatry, Pomeranian Medical University in Szczecin, Szczecin 71-460, Poland.
2
Department of Gastroenterology, Pomeranian Medical University in Szczecin, Szczecin 71-252, Poland.
3
Department of Biochemical Science, Pomeranian Medical University in Szczecin, Szczecin 71-460, Poland.
Correspondence to: Dr. Igor Łoniewski, Department of Biochemical Sciences, Pomeranian Medical University in Szczecin,
Broniewskiego 24, Szczecin 71-460, Poland. E-mail: sanprobi@sanprobi.pl
How to cite this article: Misera A, Marlicz W, Podkówka A, Łoniewski I, Skonieczna-Żydecka K. Possible application of
Akkermansia muciniphila in stress management. Microbiome Res Rep 2024;3:48. https://dx.doi.org/10.20517/mrr.2023.81

Received: 28 Dec 2023 First Decision: 16 May 2024 Revised: 30 Aug 2024 Accepted: 2 Sep 2024 Published: 10 Sep 2024
Academic Editors: Anneleen Segers, Marco Ventura Copy Editor: Pei-Yun Wang Production Editor: Pei-Yun Wang

Abstract
Akkermansia muciniphila (A. muciniphila) is a promising candidate bacterium for stress management due to its
beneficial effects on the microbiota-gut-brain axis (MGBA). As a well-known mucin-degrading bacterium in the
digestive tract, A. muciniphila has demonstrated significant benefits for host physiology. Recent research highlights
its potential in treating several neuropsychiatric disorders. Proposed mechanisms of action include the bacterium’s
outer membrane protein Amuc_1100 and potentially its extracellular vesicles (EVs), which interact with host
immune receptors and influence serotonin pathways, which are crucial for emotional regulation. Despite its
potential, the administration of probiotics containing A. muciniphila faces technological challenges, prompting the
development of pasteurized forms recognized as safe by the European Food Safety Authority (EFSA). This review
systematically examines the existing literature on the role of A. muciniphila in stress management, emphasizing the
need for further research to validate its efficacy. The review follows a structured methodology, including
comprehensive database searches and thematic data analysis, to provide a detailed understanding of the
relationship between stress, microbiota, and A. muciniphila therapeutic potential.

Keywords: Stress, postbiotics, gut barrier, psychiatry, microbiota

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
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